Reduction in gingival overgrowth associated with conversion from cyclosporin A to tacrolimus
| Autor: | H. Spratt, J. J. Marley, Colin D. Short, Christopher Irwin, S. Boomer, Alexander P. Maxwell, Robert W. G. Johnson, Jacqueline James, Gerard J. Linden, B. A. Campbell, P. S. Hull |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Adolescent Periodontal surgery medicine.medical_treatment Tacrolimus Cyclosporin a Humans Medicine Reduction (orthopedic surgery) Gingival Overgrowth business.industry Remission Induction Effective management Middle Aged medicine.disease Kidney Transplantation Surgery Gingival enlargement Transplantation Renal transplant Cyclosporine Periodontics Drug Therapy Combination Female business Immunosuppressive Agents |
| Zdroj: | Journal of Clinical Periodontology. 27:144-148 |
| ISSN: | 1600-051X 0303-6979 |
| Popis: | Background: Unsightly gingival overgrowth affects many individuals immunosuppressed with cyclosporin A (CsA). Current management involves repeated periodontal surgery and intensive hygienist support. Tacrolimus is an effective alternative immunosuppressive agent for renal transplantation which does not appear to produce gingival enlargement. Aims: The purpose of the present study was to monitor the gingival response of 4 renal transplant patients (RTPs), with clinically significant CsA-induced gingival overgrowth, after their immunosuppressive therapy was switched to tacrolimus. Methods: Intra-oral photographs and alginate impressions were taken both prior to the drug conversion and again, 6 to 9 months later. Gingival overgrowth scores were determined, from plaster models on both these occasions. Results: All of the RTPs experienced significant resolution of their gingival enlargement within the time period studied; however, only one had complete regression. Conclusion: It is concluded that conversion of RTPs with gingival overgrowth from CsA to tacrolimus may provide an effective management strategy for this clinical problem. |
| Databáze: | OpenAIRE |
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