Antimicrobial Use and Resistance Among Gram-negative Bacilli in an Italian Intensive Care Unit (ICU)
| Autor: | F. Bobbio Pallavicini, C. Mengoli, R. Fasce, Barbara Rebesco, Matteo Bassetti, Claudio Viscoli, M. P. Molinari, A. Costa, Elda Righi, M. Cruciani |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Cefotaxime
Klebsiella pneumoniae Cefepime Microbial Sensitivity Tests Drug resistance Tazobactam Microbiology Antibiotic resistance Drug Resistance Multiple Bacterial polycyclic compounds Humans Medicine Pharmacology (medical) Demography Retrospective Studies Pharmacology Cross Infection biology business.industry Length of Stay Middle Aged bacterial infections and mycoses biology.organism_classification Drug Utilization Anti-Bacterial Agents Ciprofloxacin Intensive Care Units Infectious Diseases Italy Oncology Gram-Negative Bacterial Infections business medicine.drug Piperacillin |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1973-9478 1120-009X |
| DOI: | 10.1179/joc.2006.18.3.261 |
| Popis: | Gram-negative bacilli antimicrobial resistance remains a significant problem for patients in the intensive care unit (ICU). We performed a retrospective analysis of microbiological data and antibiotic consumption over a 4-year period (2000-2003) in an Italian ICU. Pseudomonas aeruginosa and Klebsiella pneumoniae represented approximately 40% of all isolates. The most significant trend in antimicrobial use was an increase in use of 3(rd )generation cephalosporins, imipenem, and ciprofloxacin. A significant trend toward an increase in resistance rates to piperacillin, 3( rd )generation cephalosporins and ciprofloxacin was observed for K. pneumoniae and a positive correlation between resistance and drug-usage was evident for K. pneumoniae and piperacillin, cefotaxime, ceftazidime, cefepime, and ciprofloxacin, but not for piperacillin/tazobactam. No statistically significant correlations were evidenced for P. aeruginosa. Trends in resistances were studied also for Serratia spp and Proteus spp. Isolation rates of extended-spectrum beta-lactamase (ESBL)-producing strains in pathogens studied were high, especially for K. pneumoniae (72%, 160/222) and Proteus spp (41%, 18/43). In conclusion, the study showed high resistance among Gram-negative organisms isolated in the ICU and significant ESBL production. A significant correlation between antibiotic consumption and increasing resistance was evident for K. pneumoniae. |
| Databáze: | OpenAIRE |
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