Complete remission of VZV reactivation treated with valganciclovir in a patient with total lymphocyte depletion and acute kidney injury after allogeneic bone marrow transplantation
| Autor: | Pizzol Antonio, Granzotto Marilena, Paolo Tamaro, Francesca Rovere, Natalia Maximova |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Microbiology (medical)
Ganciclovir Foscarnet Herpesvirus 3 Human Adolescent viruses medicine.medical_treatment Hematopoietic stem cell transplantation medicine.disease_cause Herpes Zoster Pathology and Forensic Medicine chemistry.chemical_compound Fatal Outcome medicine Humans Valganciclovir Immunology and Allergy Bone Marrow Transplantation Creatinine business.industry Acute kidney injury Varicella zoster virus virus diseases General Medicine Acute Kidney Injury Precursor Cell Lymphoblastic Leukemia-Lymphoma Viral Load medicine.disease chemistry Immunology Female business Viral load medicine.drug |
| Zdroj: | APMIS. 123:77-80 |
| ISSN: | 0903-4641 |
| Popis: | Varicella zoster virus (VZV), a threat for hematopoietic stem cell transplantation (HSCT) recipients, is still one of the most common viral pathogens that affect these patients with a reported incidence ranging between 17% and 50% in the post transplantation period. Valganciclovir (V-GCV), a valine ester pro-drug of GCV orally administrable, has recently shown great activity against CMV infections, but there are no reports of its clinical efficacy against VZV. We here report a case history of a patient with positive serologic test for VZV, who underwent allogeneic HSCT and developed an atypical varicella-like illness. First-line therapy with foscarnet had to be discontinued due rapid development of renal impairment (creatinine: 2.60 mg/dL, urea: 130.6 mg/dL) and therefore was switched to V-GCV. The renal impairment and skin lesions of the patient fully recovered after few days of therapy, even though the patient had complete lymphocyte depletion. This is the first case of a patient with chickenpox-like illness treated successfully with V-GCV. |
| Databáze: | OpenAIRE |
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