Voltammetric studies of Cu-adriblastina complex and its effect on ssDNA-adriblastina interaction atin situ mercury film electrode
| Autor: | N. Abo E-Maali, M. Mahmoud Seliem, D. Abd El-Hady, M. Ibrahim Abdel-Hamid |
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| Rok vydání: | 2004 |
| Předmět: |
Aqueous solution
Organic Chemistry Inorganic chemistry DNA Single-Stranded chemistry.chemical_element Mercury Hydrogen-Ion Concentration Copper Mercury (element) Metal Electrolytes chemistry Doxorubicin visual_art Drug Discovery Electrochemistry visual_art.visual_art_medium Molecular Medicine Cyclic voltammetry Electrodes Oxidation-Reduction Voltammetry Stoichiometry Equilibrium constant |
| Zdroj: | Archives of Pharmacal Research. 27:1161-1167 |
| ISSN: | 1976-3786 0253-6269 |
| DOI: | 10.1007/bf02975123 |
| Popis: | Adriblastina, a cancerostatic anthracycline antibiotic, causes considerable oxidative damage to DNA molecules. The interaction of this compound with DNA was investigated using Osteryoung square wave stripping voltammetry (OSWSV) and cyclic voltammetry (CV) at an in situ mercury film electrode. It was found that the equilibrium constant of the bonded oxidized form of the drug was 63 times bigger more important than that of the bonded reduced form. Copper forms 1 metal: 2 drug stoichiometry complex which is highly stable compared to ssDNA-drug interaction and consequently inhibited the drug biochemical damaging effects. Copper complex offered sub-nanogram determination of adriblastina in aqueous and urine media. |
| Databáze: | OpenAIRE |
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