Mild Hyponatremia Is Associated with Low Skeletal Muscle Mass, Physical Function Impairment, and Depressive Mood in the Elderly
| Autor: | Satoshi Samizo, Haruki Fujisawa, Chisato Fujisawa, Masafumi Kuzuya, Kenji Toba, Yoshihisa Sugimura, Chi Hsien Huang, Takashi Sakurai, Hiroyuki Umegaki, Taiki Sugimoto |
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| Rok vydání: | 2020 |
| Předmět: |
Sarcopenia
medicine.medical_specialty lcsh:Geriatrics 03 medical and health sciences Grip strength 0302 clinical medicine Electrolyte disorder Internal medicine medicine Humans 030212 general & internal medicine Muscle Skeletal Depression (differential diagnoses) Aged Geriatrics Hand Strength medicine.diagnostic_test Depression business.industry Balance impairment Odds ratio Neuropsychological test medicine.disease Preferred walking speed lcsh:RC952-954.6 Cross-Sectional Studies Geriatrics and Gerontology Hyponatremia business 030217 neurology & neurosurgery Research Article Gait instability |
| Zdroj: | BMC Geriatrics BMC Geriatrics, Vol 21, Iss 1, Pp 1-8 (2021) |
| DOI: | 10.21203/rs.3.rs-52196/v2 |
| Popis: | Background Mild hyponatremia (serum sodium 130–135 mEq/L) is a common electrolyte disorder in the elderly. However, its association with both sarcopenia and cognitive function remains to be clarified. Therefore, here we investigated the association of mild hyponatremia with skeletal muscle mass, physical function, and cognitive function in the elderly. Methods We enrolled 75 participants with mild hyponatremia and 2907 with normonatremia (serum sodium, 136–145 mEq/L) aged ≥70 years who visited the Memory Disorder Outpatient Center of Japan’s National Center for Geriatrics and Gerontology. Skeletal muscle mass index (SMI), grip strength (GS), walking speed (WS), one-leg standing (OLS) test times, and neuropsychological test scores were determined. Results One-way analysis of covariance showed that elderly participants with mild hyponatremia had lower SMI (7.1 ± 0.2, 7.2 ± 0.2 kg/m2, p = 0.04), weaker GS (19.1 ± 1.9 vs 21.4 ± 1.8 kg, p = 0.01), slower WS (0.9 ± 0.1 vs 1.1 ± 0.1 m/s, p = 0.001), and higher GDS- 15 score (6.4 ± 0.9 vs 5.2 ± 0.9, p = 0.002) than those with normonatremia. Multiple logistic regression analysis indicated that mild hyponatremia was independently associated with sarcopenia (odds ratio [OR]: 2.2, p = 0.02), slower WS (OR: 5.3, p = 0.04) and shorter OLS time (OR: 2.5, p = 0.02) as well as with severe depressive mood (OR: 2.6 p = 0.006) but not with SMI (OR: 1.6, p = 0.2) or GS (OR: 1.9, p = 0.09). Conclusions Our results suggest that elderly people with even mild hyponatremia had physical function impairment and depressive mood. |
| Databáze: | OpenAIRE |
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