Polymorphisms in Genes Involved in the Leptin-Melanocortin Pathway are Associated with Obesity-Related Cardiometabolic Alterations in a Southern Chilean Population
| Autor: | Fernando Lanas, Rosario Dominguez Crespo Hirata, Mario Hiroyuki Hirata, Pamela Seron, Alvaro Cerda, Cristina Moreno Fajardo, Luis A. Salazar, Nicolás Saavedra, Jorge Aviles, Víctor Manríquez |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Leptin Male 0301 basic medicine Very low-density lipoprotein medicine.medical_specialty Population 030209 endocrinology & metabolism Biology Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Internal medicine Genetics medicine Humans Obesity Chile education Genetic Association Studies Metabolic Syndrome Pharmacology education.field_of_study medicine.diagnostic_test Case-control study nutritional and metabolic diseases General Medicine Odds ratio Middle Aged medicine.disease 030104 developmental biology Endocrinology Case-Control Studies Receptor Melanocortin Type 4 Receptors Leptin Molecular Medicine Female Metabolic syndrome Lipid profile Body mass index Receptor Melanocortin Type 3 |
| Zdroj: | Molecular Diagnosis & Therapy. 22:101-113 |
| ISSN: | 1179-2000 1177-1062 |
| DOI: | 10.1007/s40291-017-0306-8 |
| Popis: | Polymorphisms in genes encoding proteins of the leptin-melanocortin pathway have been associated with obesity. The involvement of these polymorphisms with changes in body mass index (BMI) and anthropometric measures could also imply a contribution to the risk of metabolic syndrome (MetS) and metabolic alterations. We evaluated the relationship of leptin-melanocortin system polymorphisms with obesity, MetS, and other metabolic alterations in Southern Chilean individuals. Two-hundred individuals were grouped as normoweight (BMI 18.0–24.9 kg/m2), overweight (BMI 25.0–29.9 kg/m2), and obese (BMI ≥ 30 kg/m2) or according to MetS status. Anthropometric measures (BMI, abdominal circumference, waist-to-hip ratio [WHR]) and biochemical parameters (glycemia and lipid profile) were evaluated. Polymorphisms LEP rs7799039, LEPR rs1137101, MC3R rs3746619 and rs3827103, and MC4R rs17782313 were evaluated by real-time PCR using allelic discrimination assays. LEPR rs1137101 GG genotype was related to reduced risk of obesity (odds ratio [OR] 0.26, 95% confidence interval [CI] 0.08–0.79; p = 0.018) and MetS (OR 0.36, 95% CI 0.15–0.88; p = 0.024), but it was not significant after Bonferroni correction for multiple tests as compared to the AA genotype (p > 0.01). Moreover, LEPR rs1137101 allele G (AG + GG) was related to lower BMI and WHR (p |
| Databáze: | OpenAIRE |
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