An examination of the effect of pretreatment of rats with Sacoglottis gabonensis bark extract, a Nigerian palmwine additive, and ethanol on macromolecular binding of aflatoxin B1
| Autor: | Z.S.C. Okoye, G.E. Neal |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Aflatoxin food.ingredient Aflatoxin B1 Serum albumin Weanling Wine Pharmacology Toxicology chemistry.chemical_compound food Aflatoxins Albumins Animals Mycotoxin Serum Albumin Ethanol biology Chemistry Plant Extracts Food additive General Medicine DNA Rats Inbred F344 Rats Biochemistry Liver visual_art Toxicity visual_art.visual_art_medium biology.protein Carcinogens Bark Food Additives Food Science Protein Binding |
| Zdroj: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 29(1) |
| ISSN: | 0278-6915 |
| Popis: | In a previous study (Okoye and Neal, Food and Chemical Toxicology 1988, 26, 679) enhanced ethanol-induced reductions in albumin-bound and unbound serum aflatoxin B1 (AFB1) and increased hepatic DNA-AFB1 binding were observed in rats treated with bark extract of Sacoglottis gabonensis, a Nigerian palmwine additive. The present study was designed to examine further the mechanism of these effects. Male weanling rats were pretreated with the bark extract or ethanol, or both, in drinking-water (at three times the levels used in the previous study) for 8 days before the ip administration of a single dose of [3H]AFB1. [In the previous study the rats were fed all three compounds simultaneously.] In contrast to the results of the previous study, when both the additive and ethanol were administered, there were no significant effects on [3H]AFB1 binding to liver or serum albumin or liver DNA. The levels of DNA-bound aflatoxin were reduced in rats given the additive or ethanol alone. |
| Databáze: | OpenAIRE |
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