Antiadipogenic Activity ofγ-Oryzanol and Its Stability in Pigmented Rice
| Autor: | Camila Renata Corrêa, Young Joo Yoon, Yoon-Mi Lee, Sang-Ik Han, Igor Otavio Minatel, Kyung-Jin Yeum, Haelim Yoon, Denise Fecchio |
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| Přispěvatelé: | Tufts University, Universidade Estadual Paulista (Unesp), Konkuk University, Rural Development Administration |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
obesity Lutein Hot Temperature Food Handling Steaming Medicine (miscellaneous) Adipose tissue Oryza Cell Line adipogenesis Mice 03 medical and health sciences chemistry.chemical_compound Drug Stability 3T3-L1 Cells Food Preservation Adipocyte Adipocytes Animals Humans Obesity Food science bioactive compound Roasting mesenchymal stem cells Adipogenesis 030109 nutrition & dietetics Nutrition and Dietetics Phenylpropionates biology Temperature Food preservation food and beverages Mesenchymal Stem Cells Pigments Biological biology.organism_classification Bioactive compound 030104 developmental biology Adipose Tissue c-oryzanol chemistry Biochemistry Seeds |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 1557-7600 1096-620X |
| DOI: | 10.1089/jmf.2015.3647 |
| Popis: | Made available in DSpace on 2018-12-11T17:29:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-07-01 Rural Development Administration γ-Oryzanol, a prevalent compound in pigmented rice varieties, has been reported to ameliorate obesity-associated metabolic disorders. Antiadipogenic activities of γ-oryzanol were determined in human adipose-derived mesenchymal stem cells and mouse-derived 3T3-L1 cells. γ-Oryzanol significantly decreased lipid accumulation and reduced glycerol-3-phosphate dehydrogenase activities in both adipocytes. In addition, γ-oryzanol in four pigmented rice varieties (black with giant embryo, brown, sugary brown, and red) was stable when stored at 4°C and also at room temperature for 22 weeks, whereas other bioactives such as lutein and β-carotene were stable only at -80°C. Furthermore, the yield of γ-oryzanol from these rice varieties was significantly increased through steaming and roasting processes. Therefore, γ-oryzanol exerts antiadipogenic activity by suppressing adipocyte differentiations and is stable in pigmented rice for an extended period of time during storage and after cooking. Thus, the intake of pigmented rice may be a useful strategy for preventing obesity. Jean Mayer USDA-Human Nutrition Research Center on Aging Tufts University Botucatu Medical School UNESP-Universidade Estadual Paulista Division of Food Bioscience College of Biomedical and Health Sciences Konkuk University Interdisciplinary Research Center for Health Konkuk University National Institute of Crop Science Rural Development Administration Botucatu Medical School UNESP-Universidade Estadual Paulista Rural Development Administration: PJ010059 |
| Databáze: | OpenAIRE |
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