Malonyldialdehyde and glyoxal act differently on low-density lipoproteins and endotheliocytes
| Autor: | Olga A. Antonova, Arthur M. Melkumyants, A. K. Tikhaze, Vadim Z. Lankin, Elena Kumskova, Sergey A. Balashov |
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| Rok vydání: | 2014 |
| Předmět: |
Lipid Peroxides
Endothelium Clinical chemistry Clinical Biochemistry Cell medicine.disease_cause Lipid peroxidation chemistry.chemical_compound Malondialdehyde medicine Humans skin and connective tissue diseases Molecular Biology Incubation Cells Cultured Electrophoresis Agar Gel Autoxidation Cell Membrane Endothelial Cells Cell Biology General Medicine Glyoxal Lipoproteins LDL medicine.anatomical_structure chemistry Biochemistry lipids (amino acids peptides and proteins) Endothelium Vascular Rheology Oxidative stress |
| Zdroj: | Molecular and cellular biochemistry. 396(1-2) |
| ISSN: | 1573-4919 |
| Popis: | Under some pathological conditions, the natural dicarbonyl compounds can accumulate in the blood. The examples are malonyldialdehyde (MDA) formed as a secondary product of lipid peroxidation of unsaturated fatty acids during atherosclerosis, and glyoxal (GOX), a homolog of MDA, which accumulates during glucose autoxidation in patients with diabetes mellitus. This study compared the influence of both dicarbonyl compounds on low-density lipoproteins (LDL) and the membrane of endotheliocytes. In comparison with GOX, MDA induced more pronounced changes in physical and chemical properties of LDL particles. On the other hand, GOX-modified LDL particles were more prone to oxidation and aggregation than MDA-modified LDL. Incubation of endotheliocytes with MDA increased cell mechanical stiffness in contrast to incubation with GOX, which decreased it. |
| Databáze: | OpenAIRE |
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