The role of tranexamic acid in prevention of hemorrhage in major spinal surgeries
| Autor: | Alireza Zali, Fatemeh Yourdkhani, Shoeib Naimian, Amir Nikouei, Iman Razavian, Afsoun Seddighi, Amir Saeid Seddighi, Seyed Mahmood Tabatabaei |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Suction (medicine)
medicine.medical_specialty spinal surgery Blood transfusion medicine.medical_treatment Placebo Loading dose tranexamic acid 03 medical and health sciences 0302 clinical medicine instrumental procedures Blood loss medicine 030212 general & internal medicine Saline business.industry General Medicine Surgery Bloody Anesthesia Original Article business 030217 neurology & neurosurgery Tranexamic acid medicine.drug |
| Zdroj: | Asian Journal of Neurosurgery |
| ISSN: | 2248-9614 1793-5482 |
| Popis: | Background: Blood loss that necessitates blood transfusion is one of the most frequent complications of major spinal surgeries. This study has been designed to evaluate the efficacy and safety of prophylactic tranexamic acid (TA) in decreasing perioperative blood loss. Materials and Methods: From January to August 2011, all the patients who needed major spinal surgeries and aged between 18 and 60-year-old were divided into two groups randomly, the experimental group received 10 mg/kg of TA 20 min after inducing the anesthesia as loading dose followed by 0.5 mg/kg/h until skin closure and the control group received equal amounts of normal saline as placebo. Intraoperative blood loss was recorded by estimating blood with the suction tube plus the number of bloody gasses. The amounts compared between the 2 groups and analyzed. Results: Forty patients were enrolled in this study in the first group intraoperative, the 1st and 2nd postoperative days, the mean blood loss were 574 ml, 80.5 ml, and 669.5 ml while in the second group were 797 ml, 124 ml, and 921.5 ml. Conclusion: TA seems to be safe and can be considered in spinal surgeries with significant excepted blood loss especially in female patients and instrumental procedures. We suggest further studies on TAs efficacy and safety in larger scales. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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