Investigation of Different Iontophoretic Currents Profiles for Short-Term Applications in Cosmetics
| Autor: | César E. Serna-Jiménez, Veronique Burnier-Yalaoui, Lien Planard-Luong, Amparo Nácher, Matilde Merino-Sanjuán, Yogeshvar N. Kalia, Mayank Singhal, Ma Amparo Martínez-Gómez, Philippe Barbarat, Sébastian Gregoire, Virginia Merino, Jennyfer Cázares-Delgadillo |
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| Rok vydání: | 2018 |
| Předmět: |
Ellagic acid
Materials science Topical penetration Pharmaceutical Science lcsh:RS1-441 Galvanic current Square unipolar pulse current 030226 pharmacology & pharmacy Electromigration Article lcsh:Pharmacy and materia medica 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine topical penetration ellagic acid galvanic current Galvanic cell Pulsed current Active ingredient Chromatography Iontophoresis Direct current square unipolar pulse current Penetration (firestop) iontophoresis Ascorbic acid chemistry ascorbic acid pulsed current |
| Zdroj: | Pharmaceutics Pharmaceutics, Vol 10, Iss 4, p 266 (2018) Volume 10 Issue 4 RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia instname |
| ISSN: | 1999-4923 |
| Popis: | [EN] This study aimed at investigating the effect of electrical current profile upon the iontophoretic transport of (i) ascorbic acid (AA) and (ii) ellagic acid (EA), into porcine skin in vitro, and the impact of the physicochemical properties of both actives on their mechanism of transport when formulated in cosmetic compositions. The experiments were performed using a proprietary iontophoretic device containing a roller to apply the formulation. Three current profiles were tested: (i) galvanic direct current (DC), (ii) square unipolar pulse current (SPC), and (iii) galvanic direct current (DC) + pulse current (PC). The skin samples were collected at different sampling points, extracted and analyzed by HPLC. Results suggested that the DC + PC mode for only 5 min was able to significantly increase the delivery of AA from o/w cosmetic compositions. The use of this current profile might improve the skin penetration of AA due to electromigration and passive diffusion, the latter being facilitated by the physical enhancement method. The SPC mode significantly improved the passage of EA in its neutral form from cosmetic o/w formulations by electroosmosis. Tailoring specific electrical current modes considering the ionization state of active ingredients would allow the design of short and personalized cosmetic treatments that significantly improve the penetration efficiency of the active ingredients and possibly reduce the doses applied. This research was entirely funded by L'Oreal, France. |
| Databáze: | OpenAIRE |
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