Atopic Dermatitis and V?24+Natural Killer T Cells
| Autor: | Demet Cicek, Fulya Ilhan, Dilara Turgut, Başak Kandi, Handan Akbulut |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Adolescent Receptors Antigen T-Cell alpha-beta T cell chemical and pharmacologic phenomena CD16 Immunoglobulin E Statistics Nonparametric Dermatitis Atopic Pathogenesis Antigen Antigens CD T-Lymphocyte Subsets medicine Humans Lectins C-Type Child Asthma biology business.industry hemic and immune systems General Medicine Atopic dermatitis Flow Cytometry medicine.disease Natural killer T cell Killer Cells Natural body regions medicine.anatomical_structure Antigens Surface Immunology biology.protein business NK Cell Lectin-Like Receptor Subfamily B |
| Zdroj: | SKINmed. 6:218-220 |
| ISSN: | 1751-7125 1540-9740 |
| Popis: | Objective Atopic dermatitis is a chronic inflammatory skin disease associated with cutaneous hyperreactivity to environmental triggers and is often the first step in the atopic march that results in asthma and allergic rhinitis. Helper T cells and their cytokines, in addition to IgE and eosinophils, play a major role in the pathogenesis of atopic dermatitis. Natural killer T (NKT) cells may play a role in atopic dermatitis status. Methods The authors examined the percentage of Valpha24+CD161+ NKT cells and CD3+CD16+ CD56+ NKT cells in peripheral blood from 23 patients with atopic dermatitis aged 8 to 35 years (mean, 21.77+/-2.88 years) and 30 healthy controls aged 18 to 32 years (mean, 24.32+/-2.44 years) by using flow cytometric analysis. The mean percentages of Valpha24+CD161+ NKT cell subtypes in the atopic dermatitis group and the healthy group were 0.29%+/-0.02% and 0.42%+/-0.05%, respectively (P Results Percentages of Valpha24+CD161+ NKT cell subtypes are significantly lower in patients with atopic dermatitis than healthy individuals. On the other hand, the CD3+CD16+CD56+ NKT cell subtype does not differ between the groups. Conclusions The reduction of Valpha24+CD161+ NKT cells subtypes may be involved in the immunopathogenesis of atopic dermatitis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text