The clinical relevance of laboratory prognostic scores for patients with radiosurgically treated brain metastases of non-pulmonary primary tumor
| Autor: | Christoph Höller, Farjad Khalaveh, Philip Pruckner, Josa M. Frischer, Manuela Schmidinger, Noemi Pavo, Anna Cho, Karl Rössler, Christian Dorfer, Brigitte Gatterbauer, Fabian Fitschek, Helena Untersteiner |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty mGPS Lung Neoplasms Neurology Neutrophils medicine.medical_treatment Kaplan-Meier Estimate Radiosurgery NLR Targeted therapy Internal medicine medicine Humans Clinical significance Retrospective Studies Prognostic scores Brain Neoplasms business.industry Proportional hazards model Melanoma Brain metastases Immunotherapy Prognosis medicine.disease Primary tumor Gamma Knife Radiosurgery Cohort Clinical Study Neurology (clinical) Laboratories business |
| Zdroj: | Journal of Neuro-Oncology |
| ISSN: | 1573-7373 0167-594X |
| DOI: | 10.1007/s11060-021-03788-6 |
| Popis: | Purpose To investigate the clinical value of the inflammation based prognostic scores for patients with radiosurgically treated brain metastases (BM) originating from non-pulmonary primary tumor (PT). Methods A retrospective analysis of 340 BM patients of different PT origin (melanoma, breast, gastrointestinal, or genitourinary cancer) was performed. Pre-radiosurgical laboratory prognostic scores, such as the Neutrophil-to-Lymphocyte Ratio (NLR), the Platelet-to-Lymphocyte Ratio (PLR), Lymphocyte-to-Monocyte Ratio (LMR), and the modified Glasgow Prognostic Score (mGPS), were investigated within 14 days before the first Gamma Knife radiosurgical treatment (GKRS1). Results In our study cohort, the estimated survival was significantly longer in patients with NLR 4 (p = 0.001) and in patients with a mGPS score of 0 (p Conclusions Summarizing previously published and present data, pre-radiosurgical mGPS and NLR groups seem to be the most effective and simple independent prognostic factors to predict clinical outcome in radiosurgically treated BM patients. |
| Databáze: | OpenAIRE |
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