Neonatal, placental, and umbilical cord blood parameters in pregnant women residing in areas with intensive pesticide application
| Autor: | Gladis Magnarelli, Natalia Guiñazú, Berta Vera, María Gabriela Rovedatti, Maria Martha Quintana |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Rural Population
0301 basic medicine Urban Population Placenta Health Toxicology and Mutagenesis Pesticide application Physiology UMBILICAL CORD BLOOD Ciencias de la Salud 010501 environmental sciences medicine.disease_cause 01 natural sciences Umbilical cord Pregnancy OSMOTIC FRAGILITY education.field_of_study biology Vaginal delivery Erythrocyte fragility Otras Medicina Básica General Medicine NEONATE PARAMETERS Fetal Blood Pollution Otras Ciencias de la Salud Medicina Básica medicine.anatomical_structure Female CIENCIAS NATURALES Y EXACTAS Adult CIENCIAS MÉDICAS Y DE LA SALUD Adolescent Otras Ciencias Biológicas Population Argentina DNA DAMAGE Superoxide dismutase SUPEROXIDE DISMUTASE Ciencias Biológicas Young Adult 03 medical and health sciences medicine Humans Environmental Chemistry Pesticides Risk factor education 0105 earth and related environmental sciences business.industry Infant Newborn Oxidative Stress 030104 developmental biology RESIDENTIAL EXPOSURE Immunology biology.protein business Biomarkers Oxidative stress |
| DOI: | 10.1007/s11356-017-9642-9 |
| Popis: | In rural populations, the proximity to areas with intensive pesticide application represents a risk factor of xenobiotic exposure. Here, we investigated whether newborns born to mothers residing in an area with intensive pesticide application show alterations in placental and neonatal morphometric standards, umbilical cord blood (UCB) biochemical parameters, and/or biomarkers related to oxidative stress and oxidative damage. Samples were collected from 151 healthy pregnant women residing in a rural area (rural group; RG) during the pesticide spraying (SS) and nonspraying (NSS) seasons, as well as from women from an urban population (control group; CG), and grouped according to the delivery type (vaginal or cesarean). In the vaginal delivery group, the placental weight and placental index were higher in the RG groups than in the CG (p = 0.01), whereas in the cesarean delivery group, newborn weight was lower in the RG-SS group than in the CG. In the RG-SS group, UCB erythrocyte osmotic fragility and the DNA damage index (DI) were higher, and superoxide dismutase (SOD) activity was lower than in the RG-NSS group. Acetylcholinesterase and SOD activities were found to be inversely correlated with the DI. Fil: Quintana, Maria Martha. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Centro de Investigaciones En Toxicología Ambiental y Agrobiotecnología del Comahue. Universidad Nacional del Comahue. Facultad de Cs.agrarias. Centro de Investigaciones En Toxicología Ambiental y Agrobiotecnología del Comahue; Argentina. Universidad Nacional del Comahue. Facultad de Medicina; Argentina Fil: Vera, Berta Emma. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Centro de Investigaciones En Toxicología Ambiental y Agrobiotecnología del Comahue. Universidad Nacional del Comahue. Facultad de Cs.agrarias. Centro de Investigaciones En Toxicología Ambiental y Agrobiotecnología del Comahue; Argentina. Universidad Nacional del Comahue. Facultad de Medicina; Argentina Fil: Magnarelli, Gladis Griselda. Universidad Nacional del Comahue. Facultad de Medicina; Argentina. Universidad Nacional del Comahue. Facultad de Ciencias del Ambiente y la Salud; Argentina Fil: Guiñazu Alaniz, Natalia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Centro de Investigaciones En Toxicología Ambiental y Agrobiotecnología del Comahue. Universidad Nacional del Comahue. Facultad de Cs.agrarias. Centro de Investigaciones En Toxicología Ambiental y Agrobiotecnología del Comahue; Argentina Fil: Rovedatti, María Gabriela. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
| Databáze: | OpenAIRE |
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