| Autor: |
Ronald J. Hill, Robert F. Baugh, Elvin Harper |
| Rok vydání: |
1985 |
| Předmět: |
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| Zdroj: |
Thrombosis Research. 38:45-59 |
| ISSN: |
0049-3848 |
| Popis: |
The effect of pepsin solubilization on the platelet aggregating activity of type I collagen and type III collagen was examined. Pepsin-digested type I collagen was unable to initiate platelet aggregation in either soluble form or as pre-formed fibrils. In contrast, pepsin-digested type III collagen was active in soluble form or as preformed fibrils. Mixtures of type I and type III collagen were assayed for platelet aggregating activity. In soluble form, these mixtures demonstrated elevated activity with increasing type III concentration. When the mixtures were tested as pre-formed fibrils, the rate of aggregation was relatively constant with the combination 75% type III and 25% type I manifesting the highest activity. The lag time for onset of aggregation was also minimized for this same type III/type I ratio. The combinations of the two collagen types formed fibrils which reflected the amounts of types I and III collagens in solution. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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