Association of Patient-Reported Outcomes and Nutrition with Body Composition in Women with Gynecologic Cancer Undergoing Post-Operative Pelvic Radiotherapy: An Observational Study
| Autor: | Ya-Ting Jan, Chi-Jung Li, Meng-Hao Wu, Tze-Chien Chen, Jie Lee, Yu-Jen Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Genital Neoplasms Female medicine.medical_treatment Nutritional Status Logistic regression patient-reported outcome Article 03 medical and health sciences 0302 clinical medicine Internal medicine Biomarkers Tumor medicine Humans TX341-641 Patient Reported Outcome Measures Pelvic Neoplasms Retrospective Studies body composition Nutrition and Dietetics Hysterectomy business.industry Nutrition. Foods and food supply Muscles Skeletal muscle Common Terminology Criteria for Adverse Events Odds ratio Middle Aged Radiation therapy Nutrition Assessment 030104 developmental biology medicine.anatomical_structure nutrition Adipose Tissue 030220 oncology & carcinogenesis pelvic radiotherapy Female Observational study Patient-reported outcome gynecologic cancer business Food Science |
| Zdroj: | Nutrients, Vol 13, Iss 2629, p 2629 (2021) Nutrients Volume 13 Issue 8 |
| ISSN: | 2072-6643 |
| Popis: | Pelvic radiotherapy is associated with gastrointestinal toxicities and deterioration of nutritional status. This study aimed to investigate the association of patient-reported outcomes (PROs) and nutritional status with body composition changes in women who underwent hysterectomy and post-operative radiotherapy for gynecologic cancer. We analyzed data of 210 patients treated with post-operative pelvic radiotherapy for gynecologic cancer between 2013 and 2018. The PRO version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) was used for gastrointestinal toxicity assessment. The Patient-Generated Subjective Global Assessment (PG-SGA) was used for nutritional assessment. Skeletal muscle index was measured from computed tomography scans at the L3 vertebral level. A reduction in skeletal muscle index ≥ 5% was classified as muscle loss. Odds ratios were calculated through logistic regression models. The PG-SGA score increased from the beginning to the end of radiotherapy (1.4 vs. 3.7, p < 0.001). Patients with PRO-CTCAE scores ≥ 3 had significantly higher PG-SGA scores at the end of radiotherapy than those with PRO-CTCAE scores ≤ 2 (8.1 vs. 2.3, p < 0.001). On multivariable analysis, PRO-CTCAE scores ≥ 3 and PG-SGA scores ≥ 4 at the end of radiotherapy were independently associated with increased risk of muscle loss (odds ratio: 8.81, p < 0.001 odds ratio: 72.96, p < 0.001, respectively). PROs and PG-SGA may be considered as markers of muscle loss after post-operative pelvic radiotherapy for gynecologic cancer. |
| Databáze: | OpenAIRE |
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