Three New Cycloartane Triterpenoids fromAstragalus bicuspis
| Autor: | Samina A. Sattar, Saud Resayes, Syed Ghulam Musharraf, Ahmed Abbaskhan, M. I. Choudhary, Abdullah Mohammed Al-Majid, Saleem Jan, Zeid A. ALOthman |
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| Rok vydání: | 2011 |
| Předmět: |
Cell Survival
Stereochemistry Plant composition Chemical structure Antiprotozoal Agents Pharmaceutical Science Analytical Chemistry Inhibitory Concentration 50 Mice Triterpenoid Drug Discovery Animals Inhibitory concentration 50 Leishmania major Cell survival Pharmacology Plants Medicinal Dose-Response Relationship Drug Molecular Structure biology Plant Extracts Chemistry Organic Chemistry Astragalus Plant biology.organism_classification Triterpenes Astragalus Complementary and alternative medicine NIH 3T3 Cells Molecular Medicine Medicine Traditional |
| Zdroj: | Planta Medica. 77:1829-1834 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-0030-1271196 |
| Popis: | Three new cycloartane triterpenoids have been isolated from Astragalus bicUSPIS Fisch. Their structures were elucidated as 23(R),24(S),25( R),26(S)-16 β/23,23/26,24/25-triepoxy-26-hydroxy-9,19-cyclolanosta-3,6-dione (1), 6 α,23,24,25-tetraol-16 β-acetoxy-23(R),24(R)-9,19-cyclanosta-3-one (2), and 6 α,23,24,25-tetraol-16 β-acetoxy-23(R),24(R)-9,19-cyclolanosta-3 β- O-xyloside (3), based on their spectroscopic analysis. All cycloartane tritepenoids exhibited weak cytotoxicities against 3T3 fibroblast cells as compared to the standard drug cycloheximide. Compounds 3 and 4 were also tested for their antileishmanial potential, and a weak activity was observed against promastigotes of Leishmania major. |
| Databáze: | OpenAIRE |
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