The growth kinetics of synovial fibroblastic cells from inflammatory and noninflammatory arthropathies
| Autor: | David Irwin, Anne Wood, Janice Ley, Tassos Anastassiades |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Pathology
medicine.medical_specialty Chemistry Growth kinetics Immunology Synovial Membrane Knee Injuries Serum concentration Fibroblasts Tibial Meniscus Injuries Arthritis Rheumatoid Kinetics Rheumatology Osteoarthritis medicine Antibiotic free Immunology and Allergy Humans Pharmacology (medical) Cell Division Cells Cultured |
| Zdroj: | Arthritis and rheumatism. 21(4) |
| ISSN: | 0004-3591 |
| Popis: | The growth kinetics of subcultured human synovial fibroblasts from 16 patients with inflammatory and noninflammatory arthropathies were studied in antibiotic free media. The experimental design allowed a clear distinction between the growth rates and final saturation densities achieved. The effects of refeeding and of the serum concentration were evaluated for each line. Inflammatory lines achieved significantly higher final saturation densities and growth rates than noninflammatory lines for most protocols, but the differences between rheumatoid and nonrheumatoid groups were less marked. Inflammatory fibroblasts demonstrated a greater independence to nutritional and growth stimulatory factors in their micro-environment than noninflammatory fibroblasts. |
| Databáze: | OpenAIRE |
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