Saponins from Sanguisorba officinalis Improve Hematopoiesis by Promoting Survival through FAK and Erk1/2 Activation and Modulating Cytokine Production in Bone Marrow
| Autor: | Shuang Chen, Xin Chen, Jianxin Ji, Yue Gao, Zhongliu Wu, Bogang Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment Biology Pharmacology Focal adhesion 03 medical and health sciences In vivo Sanguisorba officinalis Internal medicine medicine cytokine Pharmacology (medical) saponin Original Research myelosuppression apoptosis biology.organism_classification hematopoiesis Haematopoiesis Ziyuglycoside I 030104 developmental biology Endocrinology Cytokine medicine.anatomical_structure Apoptosis Sanguisorba officinalis L Bone marrow Ziyuglycoside II Platelet factor 4 |
| Zdroj: | Frontiers in Pharmacology |
| ISSN: | 1663-9812 |
| Popis: | Radix Sanguisorbae, the root of Sanguisorba officinalis L. is used as traditional Chinese medicine. In recent decades, it has been reported to be clinically effective against myelosuppression induced by chemotherapy and/ or radiotherapy. However, the underlining mechanism has not been well studied. In this work, we evaluated the hematopoietic effect of total saponins from S. officinalis L. on myelosuppressive mice induced by cyclophosphamide and by60Co-γ-irradiation and confirmed the therapeutic effect. Then, we found total saponins and their characteristic constituents Ziyuglycoside I and Ziyuglycoside II can inhibit apoptosis of TF-1 cells caused by cytokine deprivation, and promote survival of mouse bone marrow nuclear cells through focal adhesion kinase (FAK) and extracellular signal-regulated kinase 1/2 (Erk1/2) activation in vitro. In addition, they can down-regulate macrophage inflammatory protein 2 (MIP-2), platelet factor 4 (PF4) and P-selectin secretion, which are reported to be suppressive to hematopoiesis, both in vitro and in vivo. These results suggest that promotion of survival through FAK and Erk1/2 activation and inhibition of suppressive cytokines in the bone marrow is likely to be the pharmacological mechanism underlying the hematopoietic effect of saponins from S. officinalis L. |
| Databáze: | OpenAIRE |
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