BINAP/1,4-Diamine−Ruthenium(II) Complexes for Efficient Asymmetric Hydrogenation of 1-Tetralones and Analogues
| Autor: | Takeshi Ohkuma, Ryoji Noyori, Hirohito Ooka, T. Hattori, Tsutomu Inoue |
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| Rok vydání: | 2004 |
| Předmět: |
Organic Chemistry
Asymmetric hydrogenation Enantioselective synthesis chemistry.chemical_element Noyori asymmetric hydrogenation Alcohol General Medicine Medicinal chemistry Biochemistry Kinetic resolution Ruthenium chemistry.chemical_compound chemistry Diamine Organic chemistry Physical and Theoretical Chemistry BINAP Tetralones |
| Zdroj: | Organic Letters. 6:2681-2683 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | A combined system of a RuCl(2)(binap)(1,4-diamine) complex and t-C(4)H(9)OK in i-C(3)H(7)OH catalyzes enantioselective hydrogenation of various 1-tetralone derivatives and some methylated 2-cyclohexenones. Hydrogenation of 2-methyl-1-tetralone under dynamic kinetic resolution gives the cis alcohol with high ee. [reaction: see text] |
| Databáze: | OpenAIRE |
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