Bone Mineral Density and Androgen Levels in Elderly Males
| Autor: | Manuel Díaz-Curiel, E. López-Gavilanes, N. Mazer, Federico Hawkins, S. Arver, Jaume García, C. Horcajada, Ma C. Pereira, J. J. Carballal, J. Garcia e Costa, I. Garcia, A. Galvao-Telles, Ma B. López Álvarez, I. Valverde, A. Rapado, Gregorio Martínez, Luís G. Sobrinho, J. Melo Gomes, Mário Rui Mascarenhas, K. Papapietro |
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| Rok vydání: | 1999 |
| Předmět: |
Male
musculoskeletal diseases medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism Osteocalcin Body Mass Index Bone remodeling Absorptiometry Photon Endocrinology Sex hormone-binding globulin Bone Density Sex Hormone-Binding Globulin Internal medicine medicine Humans Testosterone Orthopedics and Sports Medicine Femur Insulin-Like Growth Factor I Aged Femoral neck Aged 80 and over Bone mineral Lumbar Vertebrae biology business.industry Vitamin D-Binding Protein Luteinizing Hormone Middle Aged musculoskeletal system Androgen medicine.anatomical_structure biology.protein Osteoporosis Follicle Stimulating Hormone business Luteinizing hormone |
| Zdroj: | Calcified Tissue International. 65:417-421 |
| ISSN: | 1432-0827 0171-967X |
| DOI: | 10.1007/s002239900726 |
| Popis: | To clarify the relationship of sex male hormones and bone in men, we studied in 140 healthy elderly men (aged 55–90 years) the relation between serum levels of androgens and related sex hormones, bone mineral density (BMD) at different sites, and other parameters related to bone metabolism. Our results show a slight decrease of serum-free testosterone with age, with an increase of follicle stimulating hormone (FSH) and luteinizing hormone (LH) in a third of the elderly subjects studied. BMD decreased significantly with age in all regions studied, except in the lumbar spine. We found a positive correlation between body mass index (BMI) and BMD at the lumbar spine and femoral neck (P < 0.001). No relationship was found (uni- and multivariate regression analysis) between serum androgens or sex hormone-binding globulin (SHBG) and BMD. We found a positive correlation of vitamin D binding protein (DBP) and osteocalcin with lumbar spine BMD and with BMI, DBP, IGF-1, and PTH with femoral neck BMD. In conclusion, there is a slight decline in free testosterone and BMD in the healthy elderly males. However, sex male hormones are not correlated to the decrease in hip BMD. Other age-related factors must be associated with bone loss in elderly males. |
| Databáze: | OpenAIRE |
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