Calreticulin in the immune system: ins and outs
| Autor: | Malini Raghavan, Larry Robert Peters, Sanjeeva J. Wijeyesakere, Natasha Del Cid |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Phagocytes
Protein Folding biology Endoplasmic reticulum Immunology Antigen presentation Histocompatibility Antigens Class I Intracellular Space Transporter associated with antigen processing Major histocompatibility complex Article Cell biology Tapasin Immune System MHC class I biology.protein Immunology and Allergy Cytotoxic T cell Animals Humans Calreticulin |
| Zdroj: | Trends in immunology. 34(1) |
| ISSN: | 1471-4981 |
| Popis: | Calreticulin is a calcium-binding chaperone that has several functions in the immune response. In the endoplasmic reticulum (ER), calreticulin facilitates the folding of major histocompatibility complex (MHC) class I molecules and their assembly factor tapasin, thereby influencing antigen presentation to cytotoxic T cells. Although calreticulin is normally ER-resident, it is found at the cell surface of living cancer cells and dying cells. Here, calreticulin promotes cellular phagocytic uptake. In tumor vaccine models, drugs that induce cell surface calreticulin confer enhanced tumor protection in an extracellular calreticulin-dependent manner. Much remains to be understood about the roles of calreticulin in these distinct functions. Further investigations are important towards advancing basic knowledge of glycoprotein-folding pathways, and towards developing new cancer therapeutic strategies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect