Association of polymorphisms in the first exon of mannose binding lectin gene (MBL2) in Brazilian patients with HCV infection
| Autor: | Francisco Montenegro de Melo, Luydson Richardson Silva Vasconcelos, Sergio Crovella, Ludovica Segat, Bruna Santos Silva, Luiz Claudio Arraes, Patrícia Moura |
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| Přispěvatelé: | Segat, L, SILVA VASCONCELOS, Lr, MONTENEGRO DE MELO, F, SANTOS SILVA, B, Arraes, Lc, Moura, P, Crovella, Sergio |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Genotype Hepatitis C virus Immunology Alpha interferon Interferon alpha-2 Biology medicine.disease_cause Antiviral Agents Mannose-Binding Lectin Polymerase Chain Reaction Polymorphism Single Nucleotide Polyethylene Glycols Gene Frequency Ribavirin medicine Humans Immunology and Allergy Genetic Predisposition to Disease Allele Allele frequency Genotyping Aged Case-control study Interferon-alpha Exons Hepatitis C Hepatitis C Chronic Middle Aged medicine.disease Recombinant Proteins Treatment Outcome Case-Control Studies Disease Progression Female Brazil |
| Popis: | In our study we investigated the role of the polymorphisms in the first exon of MBL2 gene in the susceptibility to HCV infection and disease progression in a Northeastern Brazilian population. One hundred and eleven patients seen at the Gastroenterology Service of the Oswaldo Cruz Hospital of the University of Pernambuco were included in this study. A total of 165 unexposed, uninfected individuals matched for place of origin were employed as healthy controls. MBL2 genotyping was performed by using a melting temperature assay. The 0 allele was significantly more frequent in the HCV positive group than the healthy controls (34% vs. 20%, p |
| Databáze: | OpenAIRE |
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