Increased type 3 iodothyronine deiodinase activity in a regrown hepatic hemangioma with consumptive hypothyroidism
| Autor: | Kazuhiko Bessho, Akihiro Yoneda, Yuri Etani, Tsuyoshi Chihara, Noriyuki Namba, Hiroaki Ichimori, Sotaro Mushiake, Tomoyuki Aoki, Keiichi Ozono, Yoko Miyoshi, Masami Murakami, Takaharu Ooue, Eiichi Morii |
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| Rok vydání: | 2009 |
| Předmět: |
Hepatic Hemangioma
endocrine system medicine.medical_specialty Time Factors endocrine system diseases Deiodinase Iodide Peroxidase Polymerase Chain Reaction Diagnosis Differential Hypothyroidism Internal medicine medicine Biomarkers Tumor Humans RNA Neoplasm biology business.industry Liver Neoplasms Infant Magnetic Resonance Imaging eye diseases Tumor associated antigen Gene Expression Regulation Neoplastic Endocrinology Liver 3-iodothyronine Pediatrics Perinatology and Child Health biology.protein Female sense organs business Hemangioma hormones hormone substitutes and hormone antagonists Follow-Up Studies |
| Zdroj: | European journal of pediatrics. 169(2) |
| ISSN: | 1432-1076 |
| Popis: | Infantile hepatic hemangioma with consumptive hypothyroidism is a rare condition.A 4-month-old girl presented with diffuse hepatic hemangiomas during treatment of congenital hypothyroidism. Serum reverse triiodothyronine was elevated, and her hypothyroidism improved concomitant with involution of the hemangioma following prednisolone and interferon-alpha administration. At 20 months of age, 7 months after discontinuing prednisolone and interferon-alpha, a focal hemangioma regrew from one of the previous lesions and was surgically resected. The expression and activity of type 3 iodothyronine deiodinase (D3) were elevated in the resected tumor tissue compared with placenta.Here, we describe a patient with consumptive hypothyroidism and diffuse infantile hepatic hemangiomas, one of which regrew after involution following pharmacotherapy. The etiology of elevated D3 activity is also discussed.It is important to identify infantile hepatic hemangioma in patients with hypothyroidism refractory to hormone replacement therapy, who have low free triiodothyronine despite high thyrotropin and normal free thyroxine levels, and long-term follow-up will be needed for these patients. |
| Databáze: | OpenAIRE |
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