Glucosamine Conjugated Gadolinium (III) Oxide Nanoparticles as a Novel Targeted Contrast Agent for Cancer Diagnosis in MRI
| Autor: | Ahmed Eleojo Musa, N Riyahi Alam, Soheila Haghgoo, Mehdi Khoobi, Tohid Mortezazadeh, Elham Gholibegloo |
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| Rok vydání: | 2020 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
lcsh:R895-920 Gadolinium Cell chemistry.chemical_element Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences chemistry.chemical_compound In vivo medicine Radiology Nuclear Medicine and imaging Radiological and Ultrasound Technology medicine.diagnostic_test Contrast media Glucose transporter Magnetic resonance imaging 021001 nanoscience & nanotechnology Magnetic Resonance Imaging Gadolinium(III) oxide 0104 chemical sciences medicine.anatomical_structure chemistry Cancer cell Cancer research Magnetic nanoparticles Original Article 0210 nano-technology |
| Zdroj: | Journal of Biomedical Physics & Engineering Journal of Biomedical Physics and Engineering, Vol 10, Iss 1, Pp 25-38 (2020) |
| ISSN: | 2251-7200 |
| DOI: | 10.31661/jbpe.v0i0.1018 |
| Popis: | Background: Glucose transporter (Glut), a cellular transmembrane receptor, has a key role in the metabolism of cell glucose and is also associated with various human carcinomas.Objective: In this study, we evaluated a magnetic resonance (MR) imaging contrast agent for tumor detection based on paramagnetic gadolinium oxide (Gd2O3) coated polycyclodextrin (PCD) and modified with glucose (Gd2O3@PCD-Glu) for the targeting of overexpressed glucose receptors.Material and Methods: In this experimental study, 3T magnetic resonance imaging (MRI) scanner was used to assess the specific interactions between Glut1-overexpressing tumor cells (MDA-MB-231) and Gd2O3@PCD-Glu NPs. Furthermore, the capacity of transporting Gd2O3@PCD-Glu NPs to tumor cells was evaluated. Results: It was found that the acquired MRI T1 signal intensity of MDA-MB-231 cells that were treated with the Gd2O3@PCD-Glu NPs increased significantly. Based on the results obtained, Gd2O3@PCD-Glu NPs can be applied in targeting Glut1-overexpressing tumor cells in vivo, as well as an MRI-targeted tumor agent to enhance tumor diagnosis. Conclusion: Results have shown that glucose-shell of magnetic nanoparticles has a key role in diagnosing cancer cells of high metabolic activity. |
| Databáze: | OpenAIRE |
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