Immunomodulatory effects of zinc and DHEA on the Th-1 immune response in rats infected with Trypanosoma cruzi
| Autor: | Leony Cristina Caetano, José Clóvis do Prado, Vânia Brazão, Míriam Paula Alonso Toldo, Fabricia Helena Santello, Marina Del Vecchio Filipin |
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| Rok vydání: | 2010 |
| Předmět: |
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medicine.medical_specialty Cellular immunity Trypanosoma cruzi medicine.medical_treatment Immunology Dehydroepiandrosterone chemistry.chemical_element Cell Count Parasitemia Zinc Nitric Oxide Interferon-gamma Immune system Adjuvants Immunologic Internal medicine medicine Animals Immunologic Factors Immunology and Allergy Macrophage Chagas Disease Rats Wistar biology Free Radical Scavengers Hematology Th1 Cells biochemical phenomena metabolism and nutrition medicine.disease biology.organism_classification Rats Steroid hormone Endocrinology chemistry Macrophages Peritoneal Cytokines hormones hormone substitutes and hormone antagonists |
| Zdroj: | Immunobiology. 215:427-434 |
| ISSN: | 0171-2985 |
| DOI: | 10.1016/j.imbio.2009.05.005 |
| Popis: | Chagas' disease is considered the sixth most important neglected tropical disease worldwide. Considerable knowledge has been accumulated concerning the role of zinc on cellular immunity. The steroid hormone dehydroepiandrosterone (DHEA) is also known to modulate the immune system. The aims of this paper were to investigate a possible synchronization of their effects on cytokines and NO production and the resistance to Trypanosoma cruzi during the acute phase of infection. It was found that zinc, DHEA or zinc and DHEA supplementation enhanced the immune response, as evidenced by a significant reduction in parasitemia levels. Zinc and DHEA supplementation exerted additive effects on the immune response by elevation of macrophage counts, and by increasing concentrations of IFN-gamma and NO. |
| Databáze: | OpenAIRE |
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