Ring substituted 3-phenyl-1-(2-pyrazinyl)-2-propen-1-ones as potential photosynthesis-inhibiting, antifungal and antimycobacterial agents
| Autor: | Asmita V. Patel, Vladimír Buchta, Veronika Opletalova, Karel Palát, Jiří Hartl |
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| Rok vydání: | 2002 |
| Předmět: |
Antifungal Agents
Magnetic Resonance Spectroscopy Stereochemistry medicine.drug_class Antitubercular Agents Molecular Conformation Pharmaceutical Science Microbial Sensitivity Tests Ring (chemistry) Antimycobacterial Chemical synthesis Structure-Activity Relationship chemistry.chemical_compound Heterocyclic Compounds Drug Discovery medicine Phenols Photosynthesis Antibacterial agent Molecular Structure Herbicides Chemistry Fungi Mycobacterium tuberculosis Carbon-13 NMR Proton NMR Enone |
| Zdroj: | Il Farmaco. 57:135-144 |
| ISSN: | 0014-827X |
| Popis: | Four series of ring substituted ( E )-3-phenyl-1-(2-pyrazinyl)-2-propen-1-ones were prepared by means of modified Claisen–Schmidt condensation of acetylpyrazines with aromatic aldehydes. The structures were confirmed by elemental analysis, IR, 1 H NMR and 13 C NMR spectra. The compounds were tested for specific biological properties and some derivatives exhibited photosynthesis-inhibiting, antifungal and antimycobacterial properties. The most pronounced effects were observed with compounds substituted with phenolic groups. Ortho -hydroxyl substituted derivatives were more potent than the corresponding para -hydroxyl substituted analogues. |
| Databáze: | OpenAIRE |
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