A pilot study on the usefulness of a new test for mass screening of colorectal cancer in Japan
| Autor: | Genichi Nakano, Kosaku Sakamoto, Yukio Nagamachi |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Colorectal cancer Pilot Projects Inflammatory bowel disease Gastroenterology Sensitivity and Specificity Japan Surgical oncology Internal medicine medicine Biomarkers Tumor Humans Mass Screening Mass screening Reagent Strips business.industry Mucin Cancer Hepatology medicine.disease female genital diseases and pregnancy complications Colorectal surgery Mucus business Colorectal Neoplasms |
| Zdroj: | Gastroenterologia Japonica. 25(4) |
| ISSN: | 0435-1339 |
| Popis: | A new screening test (Shamsuddin and Elsayed, 1988) based on the enzymatic detection of the disaccharide beta-D-Gal(1----3)-D-GalNAc in the rectal mucus of patients with colorectal (CR) cancer and precancerous conditions such as inflammatory bowel disease (IBD) and polyp (precancerous lesions) was evaluated in 85 Japanese patients. Following a 15-minute reaction, a sensitivity of 80.0% (8/10) for CR cancer and 72.2% (8/11) for precancerous lesions was obtained. The overall specificity for combined CR cancers and precancerous lesions was 62.2% (28/45). Correlation with abnormal mucin production in the tissues of CR cancer and precancerous lesions was studied by high-iron diamine-Alcian blue and/or periodic acid-Schiff-Alcian blue (pH = 1.0). The agreement of the results with this test was 77.8% (7/9) for CR cancers and 75.0% (6/8) for precancerous conditions. Because of the simplicity of this test, low cost, stability of the sample and reagents and accuracy for CR cancer and precancerous lesions, the test may have potential use for mass screening of cancer and high risk individuals, particularly CR cancer in Japan. |
| Databáze: | OpenAIRE |
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