Atypia of undetermined significance/follicular lesions of undetermined significance: What radiologists need to know
| Autor: | Neeraj Lalwani, Johnny Ling, Wencheng Li |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Thyroid nodules
Pathology medicine.medical_specialty Bethesda system Biopsy Fine-Needle Thyroid Gland 030209 endocrinology & metabolism Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Follicular phase Adenocarcinoma Follicular medicine Atypia Humans Radiology Nuclear Medicine and imaging Thyroid Neoplasms Thyroid Nodule Review Articles Ultrasonography medicine.diagnostic_test business.industry General Medicine medicine.disease 030220 oncology & carcinogenesis Neurology (clinical) business Precancerous Conditions |
| Zdroj: | Neuroradiol J |
| ISSN: | 2385-1996 |
| Popis: | Atypia of undetermined significance/follicular lesions of undetermined significance (AUS/FLUS) refers to an intermediate histologic category of thyroid nodules in The Bethesda System for Reporting Thyroid Cytopathology. Although the risk of malignancy in this category was originally cited as 5–15%, recent literature has suggested higher rates of related malignancy ranging from 38% to 55%. Malignant nodules warrant surgery with total thyroidectomy or thyroid lobectomy, whereas benign nodules can be observed or followed with serial ultrasounds (US) based on their imaging characteristics. The management of nodules with a cytopathologic diagnosis of AUS/FLUS can be difficult because theses nodules lie between the extremes of benign and malignant. The management options for such nodules include observation, repeat fine-needle aspiration, and surgery. The use of molecular genetics, the identification of suspicious US characteristics, and the recognition of additional clinical factors are all important in the development of an appropriate, tailored management approach. Institutional factors also play a crucial role. |
| Databáze: | OpenAIRE |
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