Clinical significance of plasma PAF acetylhydrolase activity measurements as a biomarker of anaphylaxis: Cross-sectional study

Autor: Andrzej Chciałowski, Agnieszka Rzeszotarska, Jolanta Korsak, Krzysztof Łukasz Piwowarek, Aleksandra Juszkiewicz, Jerzy Kruszewski
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
Allergy
PAF acetylhydrolase
Physiology
Epidemiology
Wasps
Toxicology
Pathology and Laboratory Medicine
Severity of Illness Index
Gastroenterology
Body Mass Index
Pathogenesis
Allergies
Blood plasma
Medicine and Health Sciences
Toxins
Medicine
Multidisciplinary
Predictive marker
Bees
Middle Aged
Body Fluids
Blood
Physical Sciences
Biomarker (medicine)
Female
Anatomy
Anaphylaxis
Research Article
Adult
medicine.medical_specialty
Science
Immunology
Toxic Agents
Blood Plasma
Internal medicine
Hypersensitivity
Animals
Humans
Clinical significance
Platelet Activating Factor
Aged
Arithmetic
Venoms
business.industry
Biology and Life Sciences
Insect Bites and Stings
Immunoglobulin E
medicine.disease
Sting
ROC Curve
Medical Risk Factors
Case-Control Studies
1-Alkyl-2-acetylglycerophosphocholine Esterase
Etiology
Clinical Immunology
Clinical Medicine
business
Mathematics
Biomarkers
Zdroj: PLoS ONE, Vol 16, Iss 8, p e0256168 (2021)
PLoS ONE
ISSN: 1932-6203
Popis: Introduction Platelet-activating factor (PAF) has a direct role as a mediator in the pathogenesis of various disorders with an inflammatory component, including those with allergic aetiology. The peripheral blood concentration of PAF is dynamically regulated by plasma PAF acetylhydrolase (PAF-AH). Previous research suggest that low activity of plasma PAF-AH could be a predictive marker for increased severity of some types of allergic hypersensitivity reactions–especially anaphylaxis. The purpose of the study was to evaluate the association between plasma PAF-AH activity and severity in patients with anaphylactic reactions following a wasp or bee sting. Materials and methods The study group of 89 patients was divided into two subgroups depending on the increasing severity of the most severe anaphylactic reaction in the past, which was assessed according to the Müller’s scale. The first subgroup included participants with a history of hypersensitivity reactions up to grade II. The second subgroup consisted of patients who have experienced at least one grade III or IV reactions in the past. A control group of 20 people was established. Plasma PAF-AH activity was measured using a colorimetric method. Results It has been observed that plasma activity of platelet-activating factor acetylhydrolase was significantly lower in patients with anaphylaxis history compared to the control group with negative atopic history (on average 21.38 nmol/min/ml for the control group, 9.47 nmol/min/ml for the first subgroup and 10.16 nmol/min/ml for the second subgroup, in both cases p < 0.0001). Conclusion The plasma activity of PAF-AH is a promising parameter that can help to distinguish a group of patients not threatened with development of anaphylaxis and not requiring laborious or expensive prophylactic procedures.
Databáze: OpenAIRE
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