Does Embryo Culture Medium Influence the Health and Development of Children Born after In Vitro Fertilization?
| Autor: | Clément Jimenez, Alexandra Ernst, Céline Bouillon, A. Burguet, Charline Cerf, Paul Sagot, Alexandra Chiron, Roger Leandri, Laurent Desch, Patricia Fauque, Céline Bruno, Céline Souchay |
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| Přispěvatelé: | CHRU Tours, Centre d’Assistance Médicale à la Procréation, Hôpital Paule-de-Viguier, Laboratoire de Biologie de la reproduction CECOS - [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Laboratoire d'Etude de l'Apprentissage et du Développement [Dijon] ( LEAD ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), SELAFA BIOFFICE, Laboratoire de Psychologie et NeuroCognition ( LPNC ), Université Pierre Mendès France - Grenoble 2 ( UPMF ) -Université Joseph Fourier - Grenoble 1 ( UJF ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Institut des Maladies Neurodégénératives [Bordeaux] ( IMN ), Université de Bordeaux ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Service de Gynécologie Obstétrique, Médecine Foetale et Stérilité Conjugale - Chirurgie Gynécologie et Oncologique [CHU de Dijon], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Hôpital Paule de Viguier, CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Laboratoire d'Etude de l'Apprentissage et du Développement [Dijon] (LEAD), Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB), Laboratoire de Psychologie et NeuroCognition (LPNC ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Embryology Pediatrics Maternal Health Health Status medicine.medical_treatment lcsh:Medicine Social Sciences Growth law.invention Cohort Studies Families Labor and Delivery [SCCO]Cognitive science 0302 clinical medicine Randomized controlled trial law Medicine and Health Sciences Psychology Termination of Pregnancy lcsh:Science Children [ SDV.MHEP.GEO ] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics Language 030219 obstetrics & reproductive medicine Multidisciplinary Obstetrics Obstetrics and Gynecology Laboratory Equipment Child Preschool Engineering and Technology Gestation Epigenetics Biological Cultures [ SCCO ] Cognitive science Research Article Cohort study medicine.medical_specialty Offspring Gross motor skill Equipment Fertilization in Vitro [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics Research and Analysis Methods 03 medical and health sciences Genetics medicine Humans Pregnancy In vitro fertilisation business.industry lcsh:R Embryos Cognitive Psychology Infant Newborn Biology and Life Sciences Infant Embryo culture medicine.disease Culture Media 030104 developmental biology Age Groups People and Places Birth Women's Health Cognitive Science lcsh:Q Population Groupings business Developmental Biology Neuroscience |
| Zdroj: | PLoS ONE PLoS ONE, Public Library of Science, 2016, 11 (3), pp.e0150857. 〈10.1371/journal.pone.0150857〉 PLoS ONE, Public Library of Science, 2016, 11 (3), pp.e0150857. ⟨10.1371/journal.pone.0150857⟩ PLoS ONE, Vol 11, Iss 3, p e0150857 (2016) |
| ISSN: | 1932-6203 |
| Popis: | International audience; In animal studies, extensive data revealed the influence of culture medium on embryonic development, foetal growth and the behaviour of offspring. However, this impact has never been investigated in humans. For the first time, we investigated in depth the effects of embryo culture media on health, growth and development of infants conceived by In Vitro Fertilization until the age of 5 years old. This single-centre cohort study was based on an earlier randomized study. During six months, in vitro fertilization attempts (No. 371) were randomized according to two media (Single Step Medium—SSM group) or Global medium (Global group). This randomized study was stopped prematurely as significantly lower pregnancy and implantation rates were observed in the SSM group. Singletons (No. 73) conceived in the randomized study were included (42 for Global and 31 for SSM). The medical data for gestational, neonatal and early childhood periods were extracted from medical records and parental interviews (256 variables recorded). The developmental profiles of the children in eight domains (social, self-help, gross motor, fine motor, expressive language, language comprehension, letter knowledge and number knowledge – 270 items) were compared in relation to the culture medium. The delivery rate was significantly lower in the SSM group than in the Global group (p |
| Databáze: | OpenAIRE |
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