Effect of a 24-month physical activity program on brain changes in older adults at risk of Alzheimer's disease: the AIBL active trial
| Autor: | Kay L. Cox, Bernd Merkel, Nicola T. Lautenschlager, Alexandra Gorelik, Colin L. Masters, David Ames, Victor L. Villemagne, Michelle Lai, Andrew Sanderson, Vijay K. Venkatraman, Christopher Steward, Patricia Desmond, Pramit M. Phal, Elizabeth V. Cyarto, Matthew J. Sharman, Kathryn A. Ellis, Cassandra Szoeke, Christopher C. Rowe |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Risk 0301 basic medicine Aging medicine.medical_specialty Time Factors Disease behavioral disciplines and activities 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Internal medicine Preventive Health Services mental disorders medicine Humans Dementia Cognitive Dysfunction Cognitive decline Risk factor Exercise Aged Aged 80 and over business.industry General Neuroscience Brain medicine.disease Magnetic Resonance Imaging Hyperintensity 030104 developmental biology Positron-Emission Tomography Cohort Secondary Outcome Measure Female Neurology (clinical) Geriatrics and Gerontology Alzheimer's disease business Negative Results 030217 neurology & neurosurgery Program Evaluation Developmental Biology |
| Zdroj: | Neurobiology of Aging. 89:132-141 |
| ISSN: | 0197-4580 |
| DOI: | 10.1016/j.neurobiolaging.2019.02.030 |
| Popis: | White matter hyperintensities (WMHs) are a risk factor for cognitive decline. Physical activity (PA) is associated with lower WMH. Whether long-term exposure to PA programs has beneficial effects on WMH progression in older adults with memory complaints and comorbid conditions has had limited exploration. This study explored whether a 24-month moderate-intensity PA intervention can delay the progression of WMH and hippocampus loss in older adults at risk for cognitive decline. Data acquired on magnetic resonance imaging were used to measure the progression of WMH and hippocampus loss. The results of this study showed no effect of intervention on either the primary outcome measure "WMH" or the secondary outcome measure "hippocampal volume." In addition, neither beta amyloid status nor the adherence to the intervention had any effect on the outcome. In this cohort of subjective memory complaints and mild cognitive impairment participants with vascular risk factors, there was no effect of long-term moderate-intensity PA on WMH or hippocampal loss. |
| Databáze: | OpenAIRE |
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