Gender disparities in the functional significance of anemia among apparently healthy adults

Autor:	Drorit Merkel, Roni Shouval, Ilan Goldenberg, Shaye Kivity, Ilan Ben-Zvi, Sharon Katz, Yechezkel Sidi, Arnon Nagler, Elad Maor, Shlomo Segev
Rok vydání:	2017
Předmět:	Adult Erythrocyte Indices Male Exercise stress testing medicine.medical_specialty Anemia 030204 cardiovascular system & hematology World health Young Adult 03 medical and health sciences Sex Factors 0302 clinical medicine Bruce protocol Internal medicine Humans Mass Screening Medicine 030212 general & internal medicine business.industry Age Factors Cardiorespiratory fitness Hematology General Medicine Middle Aged medicine.disease Survival Analysis Increased risk Cardiorespiratory Fitness Physical Fitness Population Surveillance Exercise Test Physical therapy Population study Functional significance Female business Follow-Up Studies
Zdroj:	European Journal of Haematology. 98:435-442
ISSN:	0902-4441
DOI:	10.1111/ejh.12849
Popis:	Background Data on the functional impact of anemia on cardiorespiratory fitness (CRF) and survival in healthy individuals are limited. Our aim was to evaluate the association between anemia thresholds, low CRF, and survival in otherwise healthy adults. Methods Study population included 16 334 apparently healthy subjects attending annual periodic health screening examinations (71 200 annual visits), including exercise stress testing (EST). Anemia was defined by the World Health Organization (WHO) or Beutler and Waalens’ (BW) criteria. Low CRF was defined as the lowest fitness quintile according to the Bruce protocol. Results The mean age was 46±10 years, and 70% were men. Mean Hb levels were 13±1 and 15±1 among women and men, respectively, with higher proportion of anemia among women. The majority of anemic subjects had mild anemia. When analyzing repeated annual visits, anemia was associated with a significant 39% and 64% increased risk of low CRF according the WHO and BW criteria only in women (n=18 672). Baseline anemia at first visit was associated with 2.6- and 1.9-fold increased risk of all-cause mortality using the WHO and BW criteria, exclusively in men (n=11 511). Conclusions Overall, the functional and prognostic impact of anemia is gender dependent, based on the WHO and BW arbitrary criteria, suggesting differing mechanism and responses.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1a4acd90b7a3df08ed98e37cf719365 https://doi.org/10.1111/ejh.12849 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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