Ovarian Morphology by Transabdominal Ultrasound Correlates With Reproductive and Metabolic Disturbance in Adolescents With PCOS

Autor: Marla E. Lujan, Beth W. Rackow, Clare A. Flannery, Lynwood Hammers, Tania S. Burgert, Heidi Vanden Brink
Rok vydání: 2017
Předmět:
Adult
medicine.medical_specialty
Adolescent
media_common.quotation_subject
030209 endocrinology & metabolism
Pilot Projects
Article
Body Mass Index
03 medical and health sciences
Follicle-stimulating hormone
0302 clinical medicine
Insulin resistance
Metabolic Diseases
Ovarian Follicle
Internal medicine
medicine
Humans
Testosterone
Menstrual cycle
media_common
Retrospective Studies
Ultrasonography
030219 obstetrics & reproductive medicine
business.industry
Hyperandrogenism
Ovary
Public Health
Environmental and Occupational Health
Glucose Tolerance Test
Luteinizing Hormone
medicine.disease
Polycystic ovary
Psychiatry and Mental health
Endocrinology
Pediatrics
Perinatology and Child Health
Homeostatic model assessment
Female
Follicle Stimulating Hormone
Luteinizing hormone
business
Infertility
Female
Polycystic Ovary Syndrome
Zdroj: J Adolesc Health
ISSN: 1879-1972
Popis: Purpose To determine whether ovarian morphology imaged using transabdominal ultrasonography reflects clinical and metabolic features in adolescents with polycystic ovary syndrome (PCOS). Methods A retrospective pilot study was conducted in 33 adolescents (12–18 years) with PCOS as defined by hyperandrogenism and irregular cycles. Adolescents underwent the following assessments at a random time during the menstrual cycle: transabdominal ultrasonography, physical examination (height, weight, and systolic and diastolic blood pressure), fasting hormonal tests (free, percent free, and total testosterone, androstenedione, follicle stimulating hormone, luteinizing hormone), and metabolic tests (including an oral glucose tolerance test, fasting and 2-hour insulin and glucose, homeostatic model assessment of insulin resistance, and whole-body insulin sensitivity index). Ultrasound images were analyzed offline for ovarian area (OA), ovarian volume (OV), follicle number per cross section (FNPS), and follicle distribution pattern. Associations among endocrine and metabolic variables with sonographic features were assessed by Spearman's rank correlation coefficients and stepwise multiple linear regression. Results Total testosterone and androstenedione, but not free testosterone, or percent free testosterone, positively correlated with OA (ρ = .515, ρ = .422, respectively), OV (ρ = .451, ρ = .382), and FNPS (ρ = .394, ρ = .474). Luteinizing hormone:follicle stimulating hormone ratio also positively correlated with ovarian size (OA, ρ = .520 and OV, ρ = .409). Unexpectedly, body mass index (ρ = −.503) and fasting glucose levels (ρ = −.393) were inversely correlated with FNPS. Total testosterone was an independent predictor of FNPS, OA, and OV as judged by stepwise multiple regression analyses. Conclusions Some aspects of ovarian morphology in adolescents with PCOS using transabdominal ultrasonography associate with markers of reproductive dysfunction and provide rationale to further investigate how ovarian morphology may reflect concurrent metabolic dysfunction.
Databáze: OpenAIRE
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