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Objects: Recently, a novel arterial stiffness parameter called cardio-ankle vascular index (CAVI) has been developed. This study was conducted in order to elucidate the predictive value of CAVI for future cardiovascular events in 1000 persons. Subjects and methods: A total of 1,000 outpatients (513 males and 487 females, mean age 63±11 years), who had the examination of CAVI between 2004 and 2006 at the center of diabetes, endocrinology and metabolism, Sakura hospital were included and followed up for 6.7±1.6 years. Those had diabetes mellitus (51.0%), hypertension (52.4%) or/and dyslipidemia (62.5%). CAVI was measured using Vasela1500 (Fukuda Denshi. Co.LTD). Results: New-onset cardiovascular events were observed in 9.0%. In subjects with cardiovascular events, lower HDL-C and higher CAVI (9.9±2.0 vs. 9.2±1.6), mean age, prevalence of hypertension, diabetes and smoking were observed. COX regression model revealed that CAVI independently increased the risk of cardio vascular events with OR of 1.13 (95% CI 1.007–1.269, p=0.038). Male, diabetes, hypertension, low HDL-C and smoking were also significant independent predictors of events. Conclusion: CAVI is an independent predictor of cardiovascular events in subjects with coronary risks. |
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