Cefazolin tissue concentrations with a prophylactic dose administered before sleeve gastrectomy in obese patients: a single centre study in 116 patients
| Autor: | Eric Letessier, L. Planche, R. Dumont, Raphaël Cinotti, Karim Asehnoune, Eric Dailly, Antoine Roquilly, L. Ronchi, Matthieu Grégoire, V. Atthar |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Sleeve gastrectomy medicine.medical_treatment 030106 microbiology Cefazolin Subcutaneous Fat Adipose tissue Bariatric Surgery Gastroenterology Drug Administration Schedule Body Mass Index 03 medical and health sciences 0302 clinical medicine Gastrectomy Internal medicine Medicine Humans Surgical Wound Infection 030212 general & internal medicine Antibiotic prophylaxis Prospective cohort study business.industry Surrogate endpoint Antibiotic Prophylaxis Middle Aged Anti-Bacterial Agents Obesity Morbid Anesthesiology and Pain Medicine medicine.anatomical_structure Female business Subcutaneous tissue medicine.drug |
| Zdroj: | British journal of anaesthesia. 120(6) |
| ISSN: | 1471-6771 |
| Popis: | Background In obese patients undergoing sleeve gastrectomy, the blood and fatty-tissue concentrations of cefazolin required for adequate antibiotic prophylaxis are uncertain. Methods This was a single centre prospective study in obese (Group A: 40≤ BMI ≤50 kg m−2) and severely obese (Group B: 50 Results One hundred and sixteen patients were included: 79 in Group A and 37 in Group B. At the beginning of the surgery, cefazolin concentration in subcutaneous fatty tissue was 12.2 (5.4) μg g−1 in Group A and 12 (6.1) μg g−1 in Group B (P=0.7). At the end, cefazolin concentrations in subcutaneous fatty tissue were 9.0 (4.9) and 7.8 (4.2) μg g−1 in Groups A and B, respectively (P=0.2). The plasma concentration of free cefazolin during surgery was higher in Group A than in Group B (P Conclusions After a 4 g dose, the concentrations of cefazolin in fatty tissue were above the 4 μg g−1 tissue concentration target, providing adequate antibiotic tissue concentrations during bariatric surgery. As cefazolin concentration in fatty tissue is a surrogate endpoint, the results should be considered in conjunction with the results on free cefazolin concentrations in subcutaneous tissue. Clinical trial registration NCT01537380. |
| Databáze: | OpenAIRE |
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