Inhibitory effects of resveratrol analogs on unopsonized zymosan-induced oxygen radical production
| Autor: | Youngsoo Kim, Kyung Rak Min, Dae-Sig Jang, Shi Yong Ryu, Il-Moo Chang, Bo-Seong Kang |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Neutrophils Resveratrol Biochemistry Antioxidants Monocytes Cell Line Mice chemistry.chemical_compound Stilbenes medicine Animals Humans Macrophage Piceid Pharmacology chemistry.chemical_classification Reactive oxygen species Dose-Response Relationship Drug Monocyte Zymosan Biological activity medicine.anatomical_structure chemistry Cell culture Luminescent Measurements Reactive Oxygen Species |
| Zdroj: | Biochemical Pharmacology. 57:705-712 |
| ISSN: | 0006-2952 |
| DOI: | 10.1016/s0006-2952(98)00350-5 |
| Popis: | Resveratrol, a natural hydroxystilbene, has been reported to have anti-inflammatory and anticarcinogenic activities. Inhibitory effects of resveratrol and its analogs on reactive oxygen species (ROS) production in unopsonized zymosan-stimulated murine macrophage Raw264.7 cells, human monocytes, and neutrophils were analyzed to investigate if the anti-inflammatory and anticarcinogenic activities of resveratrol are related to the inhibition of ROS production. Resveratrol was a potent inhibitor of ROS production in both unopsonized zymosan-stimulated Raw264.7 cells and human monocytes and neutrophils. Resveratrol exhibited 50% inhibition values (IC50) of 17 microM in activated Raw264.7 cells, 18 microM in human monocytes, and 23 microM in human neutrophils. 3,5-Dihydroxy-4'-methoxystilbene or 3,4'-dimethoxy-5-hydroxystilbene exhibited IC50 values of 63 or 73 microM in Raw264.7 cells, 51 or100 microM in human monocytes, and 10 or 37 microM in human neutrophils, respectively. Trimethylresveratrol, piceid, and 3,5-dihydroxy-4'-methoxystilbene-3-O-beta-D-glucoside were weak inhibitors of ROS production. Thus, resveratrol was identified as a potent inhibitor of ROS production, which might be one biochemical mechanism related to its anti-inflammatory and anticarcinogenic activities. The number and position of hydroxy substituents in resveratrol analogs seem to play an important role in the inhibitory potency of ROS production. |
| Databáze: | OpenAIRE |
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