Differential localisation of the metabotropic glutamate receptor mGluR1a and the ionotropic glutamate receptor GluR2/3 in neurons of the human cerebral cortex
| Autor: | L. J. Garey, Wei-Yi Ong, Y. He, K. K. Tan |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Dendritic spine Adolescent Receptors Metabotropic Glutamate medicine Humans Receptors AMPA Microscopy Immunoelectron Receptor Cerebral Cortex Neurons Chemistry General Neuroscience Glutamate receptor food and beverages Middle Aged Cell biology medicine.anatomical_structure Metabotropic receptor nervous system Cerebral cortex Metabotropic glutamate receptor Ionotropic glutamate receptor Female Pyramidal cell Neuroscience |
| Zdroj: | Experimental Brain Research. 119:367-374 |
| ISSN: | 1432-1106 0014-4819 |
| Popis: | Specimens of human cerebral cortex were obtained during neurosurgical operations and studied by immunocytochemistry and electron microscopy, using antibodies to the metabotropic glutamate receptor subunit mGluR1a and the ionotropic glutamate receptor GluR2/3. A small number of non-pyramidal neuronal cell bodies were labelled for mGluR1a. Double immunolabelling with mGluR1a and GluR2/3 showed that most pyramidal cell bodies were labelled for GluR2/3 but not for mGluR1a. Despite the non-colocalisation of these two receptor subtypes in cell bodies, however, many dendrites and dendritic spines were double-labelled for mGluR1a and GluR2/3 at electron microscopy. As there is evidence that most neurons positive for GluR2/3 are pyramidal cells, this suggests that mGluR1a is present in dendrites of pyramidal neurons, despite absent or low levels of immunoreactivity in their cell bodies. |
| Databáze: | OpenAIRE |
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