Growth hormone receptor gene variant and three-dimensional mandibular morphology
| Autor: | Mohamed Adel, Akira Kawaguchi, Hajime Ishida, Takatoshi Nakawaki, Koutaro Maki, Yu Hikita, Tetsutaro Yamaguchi, Daisuke Tomita, Ryosuke Kimura, Mutsumi Isa, Yoko Suzuki-Tomoyasu |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Adolescent Genotype Orthodontics Growth hormone receptor Mandible Biology 03 medical and health sciences Young Adult 0302 clinical medicine Imaging Three-Dimensional Japan Internal medicine Genetic variation TaqMan medicine Image Processing Computer-Assisted Maxilla Humans Saliva Genotyping Gene Genome Human Mandibular Condyle Genetic Variation 030206 dentistry Original Articles Receptors Somatotropin Cone-Beam Computed Tomography Middle Aged 030104 developmental biology Endocrinology Regression Analysis Female hormones hormone substitutes and hormone antagonists |
| Zdroj: | Angle Orthod |
| Popis: | Objective: To examine the relationship between three-dimensional mandibular morphology and growth hormone receptor (GHR) gene variants in a healthy Japanese population.Materials and Methods: The subjects, who were unrelated Japanese orthodontic patients, consisted of 64 men and 114 women. Using the Taqman genotyping assay, GHR gene rs6184 and rs6180 variants were detected in genomic DNA extracted from saliva. Mandibular volume and length were measured from cone-beam computed tomography images that were analyzed using Analyze image-processing software. The relationship between GHR gene variants and three-dimensional mandibular morphology was statistically examined.Results: Statistical significance for the relationship between the distance between the left and right coronoid processes and rs6180 was noted (P < .05).Conclusion: Our results indicate that the GHR variant rs6180 is associated with the distance between the left and right coronoid process in the Japanese subjects. |
| Databáze: | OpenAIRE |
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