Skin rash, eosinophilia, and renal impairment in a patient recently started on allopurinol
| Autor: | Michael Guma, Ashraf Jmeian, Fayez Shamoon, Razan Shamoon, Amer Hawatmeh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
musculoskeletal diseases medicine.medical_specialty congenital hereditary and neonatal diseases and abnormalities Allopurinol lcsh:Medicine Case Report 03 medical and health sciences chemistry.chemical_compound gout medicine Eosinophilia drug-induced rash with eosinophilia and systemic symptoms syndrome heterocyclic compounds Hyperuricemia Xanthine oxidase Adverse effect integumentary system business.industry lcsh:R nutritional and metabolic diseases medicine.disease Rash Dermatology Surgery Gout 030104 developmental biology chemistry skin rash medicine.symptom business medicine.drug Kidney disease |
| Zdroj: | Journal of Family Medicine and Primary Care, Vol 5, Iss 2, Pp 479-481 (2016) Journal of Family Medicine and Primary Care |
| ISSN: | 2249-4863 |
| Popis: | Allopurinol is a hypoxanthine analog which inhibits xanthine oxidase, it is a widely used medication for the treatment of hyperuricemia and gout. Allopurinol-induced drug-induced rash with eosinophilia and systemic symptoms syndrome is an infrequent, life-threatening adverse reaction of allopurinol therapy that is remarkable for the higher mortality rate with the use of allopurinol than with the use of another agent. We present a case of a 62-year-old male with a history of chronic kidney disease stage 3, hypertension and gout who developed skin rash, eosinophilia, and renal impairment 2 weeks after he was started on allopurinol therapy for gout. Allopurinol was stopped, and the patient was started on steroids. This case emphasizes that although allopurinol is commonly used the drug for the treatment of gout. However, it can be associated with serious life-threatening complications. Therefore, care should be taken when prescribing allopurinol, and it should be prescribed only for the appropriate indications. |
| Databáze: | OpenAIRE |
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