Value of diazepam ('Valium') in treatment of cardiac arrhythmias
| Autor: | R J Chambers, V Schrire, F H Spracklen |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Male
Tachycardia medicine.medical_specialty Heart Ventricles Drug Evaluation Preclinical Ventricular tachycardia Electrocardiography Dogs Internal medicine medicine Animals Humans heterocyclic compounds Sinus rhythm cardiovascular diseases Atrial tachycardia Aged Diazepam medicine.diagnostic_test business.industry digestive oral and skin physiology Arrhythmias Cardiac Atrial fibrillation Middle Aged medicine.disease Anesthesia cardiovascular system Cardiology Drug Evaluation Female medicine.symptom Cardiology and Cardiovascular Medicine business Anti-Arrhythmia Agents Atrial flutter Research Article medicine.drug |
| Zdroj: | Heart. 32:827-832 |
| ISSN: | 1355-6037 |
| Popis: | Diazepam did not alter the rate or rhythm in III patients with atrial fibrillation. In 3 out of 38 patients with atrial flutter the use of diazepam was followed by an increase in atrioventricular block. Diazepam restored sinus rhythm in I patient with atrial tachycardia (total 7 patients) and in I patient with ventricular tachycardia (total 8 patients). Experimentally in the dog diazepam raised the electrically-induced ventricular tachycardia threshold significantly. Pretreatment with diazepam did not alter significantly the dose of strophanthidin K required to induce ventricular tachycardia in the dog. The value of diazepam as a cardiac anti-arrhythmic agent should be further assessed in a controlled clinical trial, especially in patients with acute myocardial infarction. |
| Databáze: | OpenAIRE |
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