Coronary heart disease risk factors in morbidly obese women with normal glucose tolerance
| Autor: | Jose F. Caro, Walter J. Pories, Prabhaker G Khazani, Nitin Mooney, Kevin D. O'Brien, Stuart D Long, Hisham A. Barakat |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Blood Pressure Coronary Disease Body Mass Index chemistry.chemical_compound Reference Values Risk Factors Diabetes mellitus Internal medicine Hyperinsulinism Internal Medicine Hyperinsulinemia Medicine Humans Insulin Pancreatic hormone Triglycerides Apolipoproteins B Advanced and Specialized Nursing Triglyceride Apolipoprotein A-I business.industry Cholesterol Body Weight Cholesterol HDL nutritional and metabolic diseases Glucose Tolerance Test medicine.disease Obesity Obesity Morbid Endocrinology chemistry Regression Analysis Female business Complication |
| Zdroj: | Diabetes care. 16(1) |
| ISSN: | 0149-5992 |
| Popis: | Objective— To examine if the risk for CHD increases progressively with increases in the BMI of normoglycemic, hyperinsulinemic, morbidly obese women (BMI ≥ 35 kg/m2). Research Design and Methods— Insulin sensitivity was evaluated by calculating an ISI following an OGTT. There was a significant linear relationship between ISI and BMI fitted by two straight lines intersecting at a point corresponding to a BMI of 29.7 ± 1.5 kg/m2. Significant linear relationships between insulin sensitivity and BMI were obtained below and above this breakpoint. Similarly, a breakpoint for the relation between dBP and BMI corresponding to a BMI ≥ 33.7 ± 3.4 kg/m2 was obtained. Significant linear relationships between BMI and plasma fasting glucose, triglyceride, cholesterol, HDL cholesterol, sBP, or dBP were not observed in the women with a BMI > 35 kg/m2. Results— Compared with lean (BMI Conclusions— It appears that there may be a threshold of body mass up to which insulin sensitivity is associated with CHD risk. Above this threshold, there does not appear to be a progressive increase in the risk factors for CHD with increases in BMI. |
| Databáze: | OpenAIRE |
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