Characterization of three rifamycins via electrospray mass spectrometry and HPLC-thermospray mass spectrometry
| Autor: | W A, Korfmacher, J, Bloom, M I, Churchwell, T A, Getek, E B, Hansen, C L, Holder, K T, McManus |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Chromatography
Protein mass spectrometry Molecular Structure Chemistry Electrospray ionization Selected reaction monitoring Thermospray General Medicine Top-down proteomics Mass spectrometry Rifamycins Sample preparation in mass spectrometry Mass spectrometry imaging Mass Spectrometry Analytical Chemistry polycyclic compounds Rifampin Chromatography High Pressure Liquid |
| Zdroj: | Journal of chromatographic science. 31(12) |
| ISSN: | 0021-9665 |
| Popis: | Rifamycins are a class of antibiotic compounds of which rifampicin is the most commonly prescribed. Conventional electron-impact mass spectrometry of rifampicin has not been found to provide useful data. Thermospray and electrospray mass spectrometry are studied as potential tools for the analysis of rifampicin, rifamycin SV, and rifamycin B. Using thermospray and electrospray ionization, all three compounds provide significant ion intensity for either the [MH]+ or [MNa]+ ions. In addition, combined high-performance liquid chromatography-thermospray mass spectrometry provides useful analytical data for a mixture of the three rifamycins. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|