An in-Depth Analysis of the Swelling, Mechanical, Electrical, and Drug Release Properties of Agar–Gelatin Co-Hydrogels
| Autor: | Arfat Anis, Kunal Pal, Gauri Shankar Shaw, K. Uvanesh, Indranil Banerjee, Saeed M. Al-Zahrani, Preeti Madhuri Pandey, Suraj K. Nayak |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
food.ingredient Polymers and Plastics General Chemical Engineering Materials Science (miscellaneous) macromolecular substances 02 engineering and technology 010402 general chemistry complex mixtures 01 natural sciences Gelatin Viscoelasticity food Materials Chemistry medicine Agar Composite material Ciprofloxacin Hydrochloride technology industry and agriculture 021001 nanoscience & nanotechnology 0104 chemical sciences Dielectric spectroscopy Chemical engineering Drug delivery Self-healing hydrogels Swelling medicine.symptom 0210 nano-technology |
| Zdroj: | Polymer-Plastics Technology and Engineering. 56:667-677 |
| ISSN: | 1525-6111 0360-2559 |
| Popis: | Agar–gelatin-based co-hydrogels were prepared with different compositions of the agar and the gelatin fractions. The intermolecular hydrogen bonding was higher in the co-hydrogels as compared to the gelatin hydrogel. Swelling studies indicated diffusion-mediated swelling. The electrical stability of the co-hydrogels was higher as compared to the gelatin hydrogel. Though the firmness of the co-hydrogels was higher, Weichert model of viscoelasticity indicated that the inherent mechanical stability of the gelatin hydrogel was superior. The release of ciprofloxacin hydrochloride was predominately Fickian diffusion-mediated. In gist, the co-hydrogels can be tried as polymeric constructs for controlled drug delivery applications. |
| Databáze: | OpenAIRE |
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