Drug/nutrition interaction in the developing brain: Dipyrone enhances spreading depression in rats
| Autor: | Rubem Carlos Araújo Guedes, Maria Suzane da Silva Barbosa, Irya Laryssa Tenório Ramos, Vanina Cordeiro de Souza, Ana Paula Barbosa do Amaral |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Analgesic Central nervous system Dipyrone Developmental Neuroscience Internal medicine Animals Medicine Ingestion Nutritional Physiological Phenomena Antipyretic Rats Wistar Saline Analysis of Variance business.industry Anti-Inflammatory Agents Non-Steroidal Body Weight Cortical Spreading Depression Age Factors Brain Electroencephalography Drug interaction Rats Endocrinology medicine.anatomical_structure Animals Newborn Neurology Anesthesia Cortical spreading depression Female Analysis of variance business medicine.drug |
| Zdroj: | Experimental Neurology. 219:492-498 |
| ISSN: | 0014-4886 |
| DOI: | 10.1016/j.expneurol.2009.06.017 |
| Popis: | The abuse of pharmaceutical drugs and the inadequate ingestion of nutrients constitute external factors that can alter brain development, both individually and in combination. We used cortical spreading depression (CSD) as a neurophysiological parameter to investigate the combined effects of the antipyretic/analgesic/anti-inflammatory drug dipyrone and malnutrition (M) in the developing rat brain. Suckling malnourished rats (M; n=69) and well nourished controls (W; n=76) received dipyrone (300 mg/kg/day) or saline per gavage for 7 consecutive days during the 2nd, 3rd, or 4th postnatal week. At 35-45 days, CSD was recorded at 2 points in the parietal region. In both groups, dipyrone increased CSD propagation velocities compared to respective saline controls (P |
| Databáze: | OpenAIRE |
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