Regenerative effects of hyperbaric oxygen therapy and platelet-rich plasma on the osteochondral defects of rats
| Autor: | Pembe Oltulu, Ahmet Fevzi Kekeç, Abdullah Arslan, Emine Nedime Korucu, İsmail Hakkı Korucu, Mustafa Özer |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Models
Anatomic Knee Joint medicine.medical_treatment Hyperbaric oxygen Medicine Animals Regeneration Orthopedics and Sports Medicine Platelet Rats Wistar Arthrotomy Hyperbaric Oxygenation Wound Healing Iatrogenic injury business.industry Platelet-Rich Plasma Regeneration (biology) Rehabilitation Significant difference osteochondral defect hyperbaric oxygen therapy Combined Modality Therapy Knee cartilage Rats Cartilage Treatment Outcome Cartilage regeneration Anesthesia Platelet-rich plasma Surgery Original Article business |
| Zdroj: | Joint Diseases and Related Surgery |
| ISSN: | 2687-4792 2687-4784 |
| Popis: | Objectives This study aims to investigate the effects of hyperbaric oxygen (HBO) therapy and platelet-rich plasma (PRP) on the regeneration of osteochondral defects of the rats, and the synergistic effect of this combined treatment. Materials and methods This randomized, controlled, and interventional animal study was conducted between May 2014 and August 2014 Osteochondral regeneration was evaluated in four treatment groups (control, PRP, HBO, and HBO+PRP groups) at the 30th day after iatrogenic injury. Thirty-two female Wistar albino rats (weighing 248-305 g) underwent arthrotomy and osteochondral surgery on left knees. The regenerations of defects were then examined histologically by the modified version of O'Driscoll score. Results Groups that were treated with either HBO or PRP alone regenerated significantly better than the control group (p=0.01), while no significant difference was found between the HBO- and PRP-treated groups (p>0.05). The defects in group 4 (treated with both HBO and PRP) regenerated significantly better than the control group, the HBO-treated group alone, and the PRP-treated group alone (p=0.01). Conclusion The results of this study showed a synergistic effect of HBO and PRP on knee cartilage regeneration. However, the possible underlying mechanisms should be the subject of future researches. The aggregation and activation of growth factors released from platelets whose activation is increased in the hyperbaric environment may explain this effect. This may result in a better regeneration than the effect of PRP or HBO alone. |
| Databáze: | OpenAIRE |
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