Brain bases of reading fluency in typical reading and impaired fluency in dyslexia
| Autor: | Christina Triantafyllou, John D. E. Gabrieli, John Lymberis, Susan Whitfield-Gabrieli, Patricia K. Saxler, Stephanie N. Del Tufo, Joanna A. Christodoulou, Satrajit S. Ghosh |
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| Přispěvatelé: | Martinos Imaging Center at MIT, Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research at MIT, Christodoulou, Joanna, Del Tufo, Stephanie N., Lymberis, John, Saxler, Patricia K., Ghosh, Satrajit S., Triantafyllou, Christina, Gabrieli, Susan, Gabrieli, John D. E. |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Social Sciences lcsh:Medicine Nervous System Sentence processing Dyslexia Cognition Reading (process) Functional Magnetic Resonance Imaging Image Processing Computer-Assisted Medicine and Health Sciences Psychology lcsh:Science Neurolinguistics media_common Brain Mapping Multidisciplinary Cognitive Neurology 4. Education Conceptual semantics Magnetic Resonance Imaging Temporal Lobe Semantics Pattern Recognition Visual Neurology Female Anatomy Comprehension Sentence Cognitive psychology Research Article Adult Adolescent media_common.quotation_subject Cognitive Neuroscience Prefrontal Cortex Neuroimaging Fluency Phonological awareness Neuropsychology medicine Reaction Time Humans lcsh:R Biology and Life Sciences medicine.disease Reading Cognitive Science lcsh:Q Neuroscience |
| Zdroj: | PLoS ONE, Vol 9, Iss 7, p e100552 (2014) PLoS ONE Public Library of Science |
| ISSN: | 1932-6203 |
| Popis: | Although the neural systems supporting single word reading are well studied, there are limited direct comparisons between typical and dyslexic readers of the neural correlates of reading fluency. Reading fluency deficits are a persistent behavioral marker of dyslexia into adulthood. The current study identified the neural correlates of fluent reading in typical and dyslexic adult readers, using sentences presented in a word-by-word format in which single words were presented sequentially at fixed rates. Sentences were presented at slow, medium, and fast rates, and participants were asked to decide whether each sentence did or did not make sense semantically. As presentation rates increased, participants became less accurate and slower at making judgments, with comprehension accuracy decreasing disproportionately for dyslexic readers. In-scanner performance on the sentence task correlated significantly with standardized clinical measures of both reading fluency and phonological awareness. Both typical readers and readers with dyslexia exhibited widespread, bilateral increases in activation that corresponded to increases in presentation rate. Typical readers exhibited significantly larger gains in activation as a function of faster presentation rates than readers with dyslexia in several areas, including left prefrontal and left superior temporal regions associated with semantic retrieval and semantic and phonological representations. Group differences were more extensive when behavioral differences between conditions were equated across groups. These findings suggest a brain basis for impaired reading fluency in dyslexia, specifically a failure of brain regions involved in semantic retrieval and semantic and phonological representations to become fully engaged for comprehension at rapid reading rates. Ellison Medical Foundation Massachusetts Institute of Technology (MIT Class of 1976 Funds for Dyslexia Research) Martin Richmond Memorial Fund National Center for Research Resources (U.S.) (Grant Number UL1 RR025758) Harvard Catalyst. Harvard Clinical and Translational Science Center |
| Databáze: | OpenAIRE |
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