| Autor: |
W. N. Scott, John F. Smyth, Gillian L. Hirst, John M. S. Bartlett, G. J. Rabiasz, Lee A, William R. Miller, Simon P. Langdon |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
Oncology reports. 2(5) |
| ISSN: |
1021-335X |
| Popis: |
The role of the insulin-like growth factors (IGFs) in 3 cultured human ovarian cancer cell lines (PEO1, PEO4, PEO14) was investigated. All three cell lines express mRNA for IGF-I and the PEO14 cell line expresses mRNA for IGF-II. Protein expression of IGF-II was demonstrated in the PEO14 and PEO4 cell lines. All 3 cell lines expressed mRNA for the IGF type I, IGF type II and insulin receptors; the presence of type I IGF receptors was confirmed by immuno-cytochemistry. IGF-I and insulin markedly stimulated the proliferation of PEO1 and PEO4 but not PEO14 cells while all 3 lines were insensitive to the addition of exogenous IGF-II. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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