Independent and opposite associations of serum levels of omentin-1 and adiponectin with increases of glycaemia and incident type 2 diabetes in an older population: KORA F4/FF4 study
| Autor: | Matthias Blüher, Christa Meisinger, Julia M. Kannenberg, Annette Peters, Wolfgang Rathmann, Cornelia Huth, Christian Herder, Michael Roden, Matthias B. Schulze, Barbara Thorand, Clemens Wittenbecher, Maren Carstensen-Kirberg, Corinna Niersmann |
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| Rok vydání: | 2017 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Cross-sectional study Endocrinology Diabetes and Metabolism Population Adipokine 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology GPI-Linked Proteins 03 medical and health sciences 0302 clinical medicine Endocrinology Germany Lectins Internal medicine Diabetes mellitus medicine Humans Prospective Studies Prospective cohort study education Aged Aged 80 and over education.field_of_study Adiponectin business.industry Incidence General Medicine Middle Aged medicine.disease Cross-Sectional Studies Diabetes Mellitus Type 2 Glycemic Index Population Surveillance Cohort Cytokines Female business Biomarkers Follow-Up Studies |
| Zdroj: | Eur. J. Endocrinol. 177, 277-286 (2017) |
| ISSN: | 1479-683X 0804-4643 |
| Popis: | Objective Cross-sectional studies found that higher levels of the novel adipokine omentin-1 were associated with higher adiponectin and lower levels of risk factors for type 2 diabetes, but its relevance for incident type 2 diabetes is currently not understood. Therefore this study investigated whether serum omentin-1 was associated with changes in glycaemia and incident type 2 diabetes independently of adiponectin. Design and methods The study was based on participants aged 62–81 years from the population-based Cooperative Health Research in the Region of Augsburg (KORA) F4/FF4 cohort. Associations of baseline serum levels of omentin-1 and adiponectin with changes in glycaemia were assessed in 471 non-diabetic participants, and associations between both adipokines and incident type 2 diabetes were assessed in 76 cases and 430 non-cases (follow-up time 6.5 years). Multivariable linear and logistic regression models were adjusted for multiple potential confounders. Results Higher serum levels of omentin-1 were associated with increases in fasting glucose, 2-h glucose and HbA1c (all P s.d. of log2-transformed omentin-1; P = 0.032). These associations were independent from adiponectin levels, which showed associations with changes in glycaemia and risk of type 2 diabetes in the opposite direction. We found no statistically significant interactions of omentin-1 with adiponectin or sex in the association with incident type 2 diabetes (all P > 0.1). Conclusions Systemic levels of omentin-1 were positively associated with increases in glycaemia and incident type 2 diabetes in this older population. These associations were independent of potential confounders including adiponectin. |
| Databáze: | OpenAIRE |
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