Molecular evolution, diversity, and adaptation of influenza A(H7N9) viruses in China
| Autor: | Jie Wu, Oliver G. Pybus, Thomas A. Bowden, Lirong Zou, Lijun Liang, Ru Bai, Min Kang, Yi Jing, Jayna Raghwani, Jing Lu, Julien Thézé, Rhys Pryce, Shanqian Huang, Yingchao Song, Lina Yi, Pingping Zhou, Changwen Ke |
|---|---|
| Přispěvatelé: | University of Oxford [Oxford] |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Epidemiology [SDV]Life Sciences [q-bio] lcsh:Medicine adaptation avian influenza virus medicine.disease_cause Influenza A Virus H7N9 Subtype molecular epidemiology Geography Medical Phylogeny Genetics hemagglutination inhibition assay Antigenic Variation 3. Good health Molecular Evolution Diversity and Adaptation of Influenza A(H7N9) Viruses in China phylogenetics Infectious Diseases RNA Viral influenza Microbiology (medical) China Genotype Hemagglutinin (influenza) Genome Viral Biology History 21st Century Virus diversity lcsh:Infectious and parasitic diseases Birds Evolution Molecular H7N9 03 medical and health sciences respiratory infections Molecular evolution Phylogenetics Influenza Human medicine Antigenic variation Animals Humans viruses lcsh:RC109-216 Amino Acid Sequence Hemagglutination assay Molecular epidemiology molecular evolution Research lcsh:R Genetic Variation virus subtypes Influenza A virus subtype H5N1 030104 developmental biology Influenza in Birds biology.protein avian influenza |
| Zdroj: | Emerging Infectious Diseases, Vol 24, Iss 10, Pp 1795-1805 (2018) Emerging Infectious Diseases Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2018, 24 (10), pp.1795-1805. ⟨10.3201/eid2410.171063⟩ |
| ISSN: | 1080-6059 1080-6040 |
| DOI: | 10.3201/eid2410.171063⟩ |
| Popis: | The substantial increase in prevalence and emergence of antigenically divergent or highly pathogenic influenza A(H7N9) viruses during 2016-17 raises concerns about the epizootic potential of these viruses. We investigated the evolution and adaptation of H7N9 viruses by analyzing available data and newly generated virus sequences isolated in Guangdong Province, China, during 2015-2017. Phylogenetic analyses showed that circulating H7N9 viruses belong to distinct lineages with differing spatial distributions. Hemagglutination inhibition assays performed on serum samples from patients infected with these viruses identified 3 antigenic clusters for 16 strains of different virus lineages. We used ancestral sequence reconstruction to identify parallel amino acid changes on multiple separate lineages. We inferred that mutations in hemagglutinin occur primarily at sites involved in receptor recognition or antigenicity. Our results indicate that highly pathogenic strains likely emerged from viruses circulating in eastern Guangdong Province during March 2016 and are associated with a high rate of adaptive molecular evolution. |
| Databáze: | OpenAIRE |
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